Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

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Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.
Publisher
CELL PRESS
Issue Date
2010-08
Language
English
Article Type
Article
Keywords

GROWTH-FACTOR-TRAP; OVARIAN-CANCER; SIGNAL-TRANSDUCTION; VESSEL MATURATION; INHIBITION; ANTIBODY; DOMAIN; IMMUNOGLOBULIN; BEVACIZUMAB; RESISTANCE

Citation

CANCER CELL, v.18, no.2, pp.171 - 184

ISSN
1535-6108
URI
http://hdl.handle.net/10203/100911
Appears in Collection
MSE-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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