Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

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dc.contributor.authorKoh, Young-Junko
dc.contributor.authorKim, Hak-Zooko
dc.contributor.authorHwang, Seong-Ikko
dc.contributor.authorLee, Jeung-Eunko
dc.contributor.authorOh, Nu-Riko
dc.contributor.authorJung, Kee-Hoonko
dc.contributor.authorKim, Min-Ahko
dc.contributor.authorKim, Kyung-Eunko
dc.contributor.authorKim, Ho-Minko
dc.contributor.authorLim, Nam-Kyuko
dc.contributor.authorJeon, Choon-Juko
dc.contributor.authorLee, Gyun-Minko
dc.contributor.authorJeon, Byeong-Hwako
dc.contributor.authorNam, Do-Hyunko
dc.contributor.authorSung, Hoon-Kiko
dc.contributor.authorNagy, Andrasko
dc.contributor.authorYoo, Ook-Joonko
dc.contributor.authorKoh, Gou-Youngko
dc.date.accessioned2013-03-12T01:07:56Z-
dc.date.available2013-03-12T01:07:56Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2010-08-
dc.identifier.citationCANCER CELL, v.18, no.2, pp.171 - 184-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10203/100911-
dc.description.abstractTwo vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectGROWTH-FACTOR-TRAP-
dc.subjectOVARIAN-CANCER-
dc.subjectSIGNAL-TRANSDUCTION-
dc.subjectVESSEL MATURATION-
dc.subjectINHIBITION-
dc.subjectANTIBODY-
dc.subjectDOMAIN-
dc.subjectIMMUNOGLOBULIN-
dc.subjectBEVACIZUMAB-
dc.subjectRESISTANCE-
dc.titleDouble Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage-
dc.typeArticle-
dc.identifier.wosid000281052000010-
dc.identifier.scopusid2-s2.0-77955534812-
dc.type.rimsART-
dc.citation.volume18-
dc.citation.issue2-
dc.citation.beginningpage171-
dc.citation.endingpage184-
dc.citation.publicationnameCANCER CELL-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorKim, Ho-Min-
dc.contributor.localauthorLee, Gyun-Min-
dc.contributor.localauthorYoo, Ook-Joon-
dc.contributor.localauthorKoh, Gou-Young-
dc.contributor.nonIdAuthorLim, Nam-Kyu-
dc.contributor.nonIdAuthorJeon, Choon-Ju-
dc.contributor.nonIdAuthorJeon, Byeong-Hwa-
dc.contributor.nonIdAuthorNam, Do-Hyun-
dc.contributor.nonIdAuthorSung, Hoon-Ki-
dc.contributor.nonIdAuthorNagy, Andras-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCellcycle-
dc.subject.keywordPlusGROWTH-FACTOR-TRAP-
dc.subject.keywordPlusOVARIAN-CANCER-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusVESSEL MATURATION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusANTIBODY-
dc.subject.keywordPlusDOMAIN-
dc.subject.keywordPlusIMMUNOGLOBULIN-
dc.subject.keywordPlusBEVACIZUMAB-
dc.subject.keywordPlusRESISTANCE-
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