HIGH-DENSITY CELL-CULTURE BY MEMBRANE-BASED CELL RECYCLE

Cited 55 time in webofscience Cited 0 time in scopus
  • Hit : 284
  • Download : 0
Enhancement of productivity of a bioprocess necessitates continuous operation of bioreactors with high biomass concentrations than are possible in conventional batch, fed-batch or continuous modes of culture. Membrane-based cell recycle has been effectively used to maintain high cell concentrations in bioreactors. This review compares membrane-based cell recycle operation with other such high density cell culture systems as immobilized cell reactors and reactors with cell recycle by centrifugation or gravity sedimentation. A theoretical of production of primary and secondary metabolites in membrane-based recycle systems is presented. Operation of this type of system is discussed with examples from aerobic and anaerobic fermentations.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
1994
Language
English
Article Type
Review
Keywords

HOLLOW-FIBER BIOREACTOR; PRODUCTIVITY ETHANOL FERMENTATIONS; HIGH-CONCENTRATION CULTIVATION; CROSS-FLOW FILTRATION; ESCHERICHIA-COLI; CLOSTRIDIUM-ACETOBUTYLICUM; SACCHAROMYCES-CEREVISIAE; RETENTION CULTURE; ZYMOMONAS-MOBILIS; ACID PRODUCTION

Citation

BIOTECHNOLOGY ADVANCES, v.12, no.3, pp.467 - 487

ISSN
0734-9750
DOI
10.1016/0734-9750(94)90020-5
URI
http://hdl.handle.net/10203/64390
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 55 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0