Browse "BS-Journal Papers(저널논문)" by Author Lee, Gyun Min
Showing results 53 to 112 of 112
| Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture Ha, Tae Kwang; Kim, Dongil; Kim, Che Lin; Grav, Lise Marie; Lee, Gyun Min, BIOTECHNOLOGY ADVANCES, v.54, 2022-01 |
| FEASIBILITY STUDY ON THE USE OF CALCIUM ALGINATE-ENTRAPPED HYBRIDOMA CELLS FOR IGM PRODUCTION Kim, SJ; Han, BK; Lee, Gyun Min, BIOPROCESS ENGINEERING, v.12, no.1-2, pp.65 - 70, 1995-12 |
| FEASIBILITY STUDY ON THE USE OF HYPEROSMOLAR MEDIUM FOR IMPROVED ANTIBODY-PRODUCTION OF HYBRIDOMA CELLS IN A LONG-TERM, REPEATED-FED BATCH CULTURE Park, Sung Young; Lee, Gyun Min, BIOPROCESS ENGINEERING, v.13, no.2, pp.79 - 86, 1995-12 |
| Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures Yoon, Chansik; Kim, Dongil; Lim, Ju Hyeon; Lee, Gyun Min, BIOTECHNOLOGY JOURNAL, v.15, no.10, 2020-10 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion Gutierrez, Jahir M.; Feizi, Amir; Li, Shangzhong; Kallehauge, Thomas B.; Hefzi, Hooman; Grav, Lise M.; Ley, Daniel; et al, NATURE COMMUNICATIONS, v.11, no.1, pp.1 - 10, 2020-01 |
| Glutamine substitution: the role it can play to enhance therapeutic protein production Ha, Tae Kwang; Lee, Gyun Min, PHARMACEUTICAL BIOPROCESSING, v.3, no.3, pp.249 - 261, 2015 |
| Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies Yu, Da Young; Lee, Sang Yoon; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.5, pp.1367 - 1372, 2018-05 |
| Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; Hansen, Henning Gram; Arnsdorf, Johnny; Nallapareddy, Saranya; Voldborg, Bjorn; et al, METABOLIC ENGINEERING, v.52, pp.143 - 152, 2019-03 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Lee, Gyun Min, AUTOPHAGY, v.12, no.1, pp.1 - 222, 2016 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, AUTOPHAGY, v.17, no.1, pp.1 - 382, 2021-05 |
| Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 cells Lee, Sojeong; Kim, Mi Gyeom; Kim, Nury; Heo, Won Do; Lee, Gyun Min, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.21, no.3, pp.439 - 445, 2016-06 |
| Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening Kim, Su Hyun; Shin, Seunghyeon; Baek, Minhye; Xiong, Kai; Karottki, Karen Julie la Cour; Hefzi, Hooman; Grav, Lise Marie; et al, METABOLIC ENGINEERING, v.80, pp.66 - 77, 2023-11 |
| IMMOBILIZATION CAN IMPROVE THE STABILITY OF HYBRIDOMA ANTIBODY PRODUCTIVITY IN SERUM-FREE MEDIA Lee, Gyun Min; Palsson, BO, BIOTECHNOLOGY AND BIOENGINEERING, v.36, no.10, pp.1049 - 1055, 1990-12 |
| IMMOBILIZATION OF ZYMOMONAS-MOBILIS AND AMYLOGLUCOSIDASE FOR ETHANOL-PRODUCTION FROM SAGO STARCH Kim, C.H.; Lee, Gyun Min; Abidin, Z.; Han, M.H.; Rhee, S.K., ENZYME AND MICROBIAL TECHNOLOGY, v.10, no.7, pp.426 - 430, 1988-07 |
| Improving bone morphogenetic protein (BMP) production in CHO cells through understanding of BMP synthesis, signaling and endocytosis Kim, Kyungsoo; Kim, Mi Gyeom; Lee, Gyun Min, BIOTECHNOLOGY ADVANCES, v.62, 2023-01 |
| Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines Kim, Che Lin; Lee, Gyun Min, METABOLIC ENGINEERING, v.52, pp.57 - 67, 2019-03 |
| Improving the production of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis Kim, Che Lin; Jung, Mi Yeong; Kim, Young Sik; Jang, Ju Woong; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.10, pp.2565 - 2575, 2018-10 |
| Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Lee, Gyun Min, BIOTECHNOLOGY ADVANCES, v.35, no.1, pp.64 - 76, 2017-01 |
| Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells Kim, Su Hyun; Baek, Minhye; Park, Sungje; Shin, Seunghyeon; Lee, Jae Seong; Lee, Gyun Min, METABOLIC ENGINEERING, v.69, pp.73 - 86, 2022-01 |
| In vitro induction of in vivo–relevant stellate astrocytes in 3D brain-derived, decellularized extracellular matrices Han, Sol; Kim, Jungnam; Kim, Su Hyun; Youn, Wongu; Kim, Jihoo; Ji, Gil Yong; Yang, Seoin; et al, ACTA BIOMATERIALIA, v.172, pp.218 - 233, 2023-12 |
| Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells Lee, Joo Hyoung; Lim, Sung-Min; Park, Sun-Hye; Min, Jeong-Ki; Lee, Gyun Min; Kim, Yeon-Gu, PROCESS BIOCHEMISTRY, v.55, pp.182 - 186, 2017-04 |
| Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures Ha, Tae Kwang; Hansen, Anders Holmgaard; Kildegaard, Helene Faustrup; Lee, Gyun Min, METABOLIC ENGINEERING, v.57, pp.182 - 192, 2020-01 |
| Limitations to the development of recombinant human embryonic kidney 293E cells using glutamine synthetase-mediated gene amplification: Methionine sulfoximine resistance Yu, Da Young; Noh, Soo Min; Lee, Gyun Min, JOURNAL OF BIOTECHNOLOGY, v.231, pp.136 - 140, 2016-08 |
| MICROENCAPSULATED HUMAN BONE-MARROW CULTURES - A POTENTIAL CULTURE SYSTEM FOR THE CLONAL OUTGROWTH OF HEMATOPOIETIC PROGENITOR CELLS Levee, MG; Lee, Gyun Min; Paek, SH; Palsson, BO, BIOTECHNOLOGY AND BIOENGINEERING, v.43, no.8, pp.734 - 739, 1994-04 |
| Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation Grav, Lise Marie; Sergeeva, Dania; Lee, Jae Seong; de Mas, Igor Marin; Lewis, Nathan E.; Andersen, Mikael Rordam; Nielsen, Lars Keld; et al, ACS SYNTHETIC BIOLOGY, v.7, no.9, pp.2148 - 2159, 2018-09 |
| Mitigating Clonal Variation in Recombinant Mammalian Cell Lines Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E.; Lee, Gyun Min, TRENDS IN BIOTECHNOLOGY, v.37, no.9, pp.931 - 942, 2019-09 |
| Mitigating transcriptional bottleneck using a constitutively active transcription factor, VP16-CREB, in mammalian cells Yoon, Chansik; Baek, Kyoung Eun; Kim, Dongil; Lee, Gyun Min, METABOLIC ENGINEERING, v.80, pp.33 - 44, 2023-11 |
| Morphological selection of parental Chinese hamster ovary cell clones exhibiting high-level expression of recombinant protein Chung, JY; Kim, TK; Lee, Gyun Min, BIOTECHNIQUES, v.29, no.4, pp.768 - 774, 2000-10 |
| Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells Sergeeva, Daria; Lee, Gyun Min; Nielsen, Lars Keld; Grav, Lise Marie, ACS SYNTHETIC BIOLOGY, v.9, no.9, pp.2546 - 2561, 2020-09 |
Multiplex secretome engineering enhances recombinant protein production and purity Kol, Stefan; Ley, Daniel; Wulff, Tune L.; Decker, Marianne; Arnsdorf, Johnny; Schoffelen, Sanne; Hansen, Anders Holmgaard; et al, NATURE COMMUNICATIONS, v.11, no.1, 2020-04 |
| Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression Lee, Jung-Eun; Kim, Chan; Yang, Hannah; Park, Intae; Oh, Nuri; Hua, Serenus; Jeong, Haneul; et al, MOLECULAR CANCER THERAPEUTICS, v.14, no.2, pp.470 - 479, 2015-02 |
| OBSERVATIONS CONSISTENT WITH AUTOCRINE STIMULATION OF HYBRIDOMA CELL-GROWTH AND IMPLICATIONS FOR LARGE-SCALE ANTIBODY-PRODUCTION Lee, Gyun Min; Kaminski, MS; Palsson, BO, BIOTECHNOLOGY LETTERS, v.14, no.4, pp.257 - 262, 1992-12 |
| One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment Grav, Lise Marie; Lee, Jae Seong; Gerling, Signe; Kallehauge, Thomas Beuchert; Hansen, Anders Holmgaard; Kol, Stefan; Lee, Gyun Min; et al, BIOTECHNOLOGY JOURNAL, v.10, no.9, pp.1446 - 1456, 2015-09 |
| Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production Kim, N.S.; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.71, no.3, pp.184 - 193, 2001-08 |
| Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line Oh, DJ; Lee, Gyun Min; Francis, K.; Palsson, BO, CYTOMETRY, v.36, no.4, pp.312 - 318, 1999-08 |
| PLASMID MAINTENANCE AND GROWTH OF RECOMBINANT SACCHAROMYCES-CEREVISIAE PRODUCING HEPATITIS-B VIRUS SURFACE-ANTIGEN Lee, Gyun Min; Song, K.B.; Rhee, S.K.; Han, M.H., BIOTECHNOLOGY LETTERS, v.8, no.6, pp.385 - 390, 1986-12 |
| PRODUCTION OF MONOCLONAL-ANTIBODY USING FREE-SUSPENDED AND IMMOBILIZED HYBRIDOMA CELLS - EFFECT OF SERUM Lee, Gyun Min; Varma, A.; Palsson, B.O., BIOTECHNOLOGY AND BIOENGINEERING, v.38, no.8, pp.821 - 830, 1991 |
| Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells Park, Jin-Hyoung; Jin, Jong Hwa; Lim, Myung Sin; An, Hyun Joo; Kim, Jong Won; Lee, Gyun Min, SCIENTIFIC REPORTS, v.7, no.0, pp.1 - 13, 2017-03 |
| Proteomic analysis of host cell protein dynamics in the supernatant of Fc-fusion protein-producing CHO DG44 and DUKX-B11 cell lines in batch and fed-batch cultures Park, Jin-Hyoung; Jin, Jong Hwa; Ji, In Jung; An, Hyun Joo; Kim, Jong Won; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.114, no.10, pp.2267 - 2278, 2017-10 |
| Purification of TNFR-Fc produced in recombinant CHO cells: Characterization of product-related impurities Min, Kyunghyun; Lee, Gyun Min, PROCESS BIOCHEMISTRY, v.50, no.8, pp.1313 - 1317, 2015-08 |
| Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress Shin, Seunghyeon; Kim, Su Hyun; Park, Jong-Ho; Lee, Jae Seong; Lee, Gyun Min, METABOLIC ENGINEERING, v.72, pp.247 - 258, 2022-07 |
| Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference Xiong, Kai; Marquart, Kim Fabiano; Karottki, Karen Julie la Cour; Li, Shangzhong; Shamie, Isaac; Lee, Jae Seong; Gerling, Signe; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.116, no.7, pp.1813 - 1819, 2019-06 |
| Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells Noh, Soo Min; Park, Jin-Hyoung; Lim, Myung Sin; Kim, Jong Won; Lee, Gyun Min, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.101, no.3, pp.1035 - 1045, 2017-02 |
| Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing Jae Seong Lee; Park, Jin-Hyoung; Ha, Tae Kwang; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; Kildegaard, Helene Faustrup; et al, ACS SYNTHETIC BIOLOGY, v.7, no.12, pp.2867 - 2878, 2018-12 |
| Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion Kallehauge, Thomas Beuchert; Li, Shangzhong; Pedersen, Lasse Ebdrup; Ha, Tae Kwang; Ley, Daniel; Andersen, Mikael Rordam; Kildegaard, Helene Faustrup; et al, SCIENTIFIC REPORTS, v.7, pp.1 - 10, 2017-01 |
| Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7 Kim, Mi Gyeom; Kim, Che Lin; Kim, Young Sik; Jang, Ju Woong; Lee, Gyun Min, SCIENTIFIC REPORTS, v.11, no.1, 2021-02 |
| Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins Jeong, Yeong Ran; Kim, Sun Young; Park, Young Sam; Lee, Gyun Min, JOURNAL OF PHARMACEUTICAL SCIENCES, v.107, no.7, pp.1831 - 1841, 2018-07 |
| SIMULTANEOUS SACCHARIFICATION AND ETHANOL FERMENTATION OF SAGO STARCH USING IMMOBILIZED ZYMOMONAS-MOBILIS Lee, Gyun Min; Kim, C.H.; Lee, K.J.; Yusof, Z.A.Mohd.; Han, M.H.; Rhee, S.K., JOURNAL OF FERMENTATION TECHNOLOGY, v.64, no.4, pp.293 - 297, 1986-12 |
| Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures Kim, Dongil; Yoon, Chansik; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.119, no.3, pp.820 - 831, 2022-03 |
| STABILITY OF ANTIBODY PRODUCTIVITY IS IMPROVED WHEN HYBRIDOMA CELLS ARE ENTRAPPED IN CALCIUM ALGINATE BEADS Lee, Gyun Min; Palsson, B.O., BIOTECHNOLOGY AND BIOENGINEERING, v.42, no.9, pp.1131 - 1135, 1993-11 |
| STABILITY OF TRANSFECTOMAS PRODUCING CHIMERIC ANTIBODY AGAINST THE PRE-S2 SURFACE-ANTIGEN OF HEPATITIS-B VIRUS DURING A LONG-TERM CULTURE Bae, Sung Won; Hong, Hyo Jeong; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.47, no.2, pp.243 - 251, 1995-12 |
| Streamlined Human Cell-Based Recombinase-Mediated Cassette Exchange Platform Enables Multigene Expression for the Production of Therapeutic Proteins Shin, Seunghyeon; Kim, Su Hyun; Lee, Jae Seong; Lee, Gyun Min, ACS SYNTHETIC BIOLOGY, v.10, no.7, pp.1715 - 1727, 2021-07 |
| Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering Pristovsek, Nusa; Nallapareddy, Saranya; Grav, Lise Marie; Hefzi, Hooman; Lewis, Nathan E.; Rugbjerg, Peter; Hansen, Henning Gram; et al, ACS SYNTHETIC BIOLOGY, v.8, no.4, pp.758 - 774, 2019-04 |
| Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture Lee, namil; Shin, Jongoh; Park, Jin-Hyoung; Lee, Gyun Min; Suhyung Cho; Cho, Byung-Kwan, ACS SYNTHETIC BIOLOGY, v.5, no.11, pp.1211 - 1219, 2016-11 |
| The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures Park, Jin-Hyoung; Lim, Myung Sin; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun Min, BIOTECHNOLOGY PROGRESS, v.32, no.5, pp.1113 - 1122, 2016-09 |
| Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile Lee, Jong Hyun; Jeong, Yeong Ran; Kim, Yeon-Gu; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.114, no.8, pp.1721 - 1732, 2017-08 |
| Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine Baek, Eric H; Lee, Jae Seong; Lee, Gyun Min, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.9, pp.2243 - 2254, 2018-09 |
| Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept Pristovsek, Nusa; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Lee, Gyun Min; Andersen, Mikael Rordam; Kildegaard, Helene Faustrup, BIOTECHNOLOGY JOURNAL, v.13, no.3, pp.1 - 10, 2018-03 |
| Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity Park, Jin-Hyoung; Noh, Soo Min; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun Min, BIOTECHNOLOGY JOURNAL, v.11, no.4, pp.487 - 496, 2016-04 |
| Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; Lundqvist, Magnus; Rockberg, Johan; et al, SCIENTIFIC REPORTS, v.5, 2015-12 |
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