Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition

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The mammalian Hippo signaling pathway has been implicated in the self-renewal and differentiation of stem and progenitor cells. MST1 and MST2 (MST1/2) are core serine-threonine kinases in the Hippo signaling pathway, one of which, MST1, has been extensively investigated for its role in T cell and myeloid cell function. These studies have identified MST1 as a promising therapeutic target in immunological disease. However, the roles of MST1/2 in hematopoietic stem cell (HSC) function in vivo are not fully understood. Here, we report that mice with a conditional deletion of Mst1/2 exhibit impaired hematopoietic stem and progenitor cell (HSPC) function under stress condition. Furthermore, Mst1/2 deletion markedly altered mature cell output. Therefore, MST1/2 are indispensable for maintenance as well as function of stem and progenitor cells under steady state conditions and with transplantation stress.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2018-01
Language
English
Article Type
Article
Keywords

HIPPO SIGNALING PATHWAY; SIZE CONTROL; MST1; PROLIFERATION; REGENERATION; ADHESION

Citation

SCIENTIFIC REPORTS, v.8

ISSN
2045-2322
DOI
10.1038/s41598-018-19637-y
URI
http://hdl.handle.net/10203/240095
Appears in Collection
BS-Journal Papers(저널논문)
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