DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Da-Hye | ko |
dc.contributor.author | Kim, Tae-Shin | ko |
dc.contributor.author | Lee, Dongjun | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2018-02-21T05:34:17Z | - |
dc.date.available | 2018-02-21T05:34:17Z | - |
dc.date.created | 2018-01-29 | - |
dc.date.created | 2018-01-29 | - |
dc.date.created | 2018-01-29 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.8 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240095 | - |
dc.description.abstract | The mammalian Hippo signaling pathway has been implicated in the self-renewal and differentiation of stem and progenitor cells. MST1 and MST2 (MST1/2) are core serine-threonine kinases in the Hippo signaling pathway, one of which, MST1, has been extensively investigated for its role in T cell and myeloid cell function. These studies have identified MST1 as a promising therapeutic target in immunological disease. However, the roles of MST1/2 in hematopoietic stem cell (HSC) function in vivo are not fully understood. Here, we report that mice with a conditional deletion of Mst1/2 exhibit impaired hematopoietic stem and progenitor cell (HSPC) function under stress condition. Furthermore, Mst1/2 deletion markedly altered mature cell output. Therefore, MST1/2 are indispensable for maintenance as well as function of stem and progenitor cells under steady state conditions and with transplantation stress. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | HIPPO SIGNALING PATHWAY | - |
dc.subject | SIZE CONTROL | - |
dc.subject | MST1 | - |
dc.subject | PROLIFERATION | - |
dc.subject | REGENERATION | - |
dc.subject | ADHESION | - |
dc.title | Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition | - |
dc.type | Article | - |
dc.identifier.wosid | 000422716900076 | - |
dc.identifier.scopusid | 2-s2.0-85040793894 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-018-19637-y | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Lee, Dongjun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HIPPO SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SIZE CONTROL | - |
dc.subject.keywordPlus | MST1 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | HIPPO SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SIZE CONTROL | - |
dc.subject.keywordPlus | MST1 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | ADHESION | - |
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