Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition

Cited 9 time in webofscience Cited 0 time in scopus
  • Hit : 498
  • Download : 154
DC FieldValueLanguage
dc.contributor.authorLee, Da-Hyeko
dc.contributor.authorKim, Tae-Shinko
dc.contributor.authorLee, Dongjunko
dc.contributor.authorLim, Dae-Sikko
dc.date.accessioned2018-02-21T05:34:17Z-
dc.date.available2018-02-21T05:34:17Z-
dc.date.created2018-01-29-
dc.date.created2018-01-29-
dc.date.created2018-01-29-
dc.date.issued2018-01-
dc.identifier.citationSCIENTIFIC REPORTS, v.8-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/240095-
dc.description.abstractThe mammalian Hippo signaling pathway has been implicated in the self-renewal and differentiation of stem and progenitor cells. MST1 and MST2 (MST1/2) are core serine-threonine kinases in the Hippo signaling pathway, one of which, MST1, has been extensively investigated for its role in T cell and myeloid cell function. These studies have identified MST1 as a promising therapeutic target in immunological disease. However, the roles of MST1/2 in hematopoietic stem cell (HSC) function in vivo are not fully understood. Here, we report that mice with a conditional deletion of Mst1/2 exhibit impaired hematopoietic stem and progenitor cell (HSPC) function under stress condition. Furthermore, Mst1/2 deletion markedly altered mature cell output. Therefore, MST1/2 are indispensable for maintenance as well as function of stem and progenitor cells under steady state conditions and with transplantation stress.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectHIPPO SIGNALING PATHWAY-
dc.subjectSIZE CONTROL-
dc.subjectMST1-
dc.subjectPROLIFERATION-
dc.subjectREGENERATION-
dc.subjectADHESION-
dc.titleMammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition-
dc.typeArticle-
dc.identifier.wosid000422716900076-
dc.identifier.scopusid2-s2.0-85040793894-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/s41598-018-19637-y-
dc.contributor.localauthorLim, Dae-Sik-
dc.contributor.nonIdAuthorLee, Dongjun-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHIPPO SIGNALING PATHWAY-
dc.subject.keywordPlusSIZE CONTROL-
dc.subject.keywordPlusMST1-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusADHESION-
dc.subject.keywordPlusHIPPO SIGNALING PATHWAY-
dc.subject.keywordPlusSIZE CONTROL-
dc.subject.keywordPlusMST1-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusADHESION-
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 9 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0