Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery

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Introduction: The skin, as the largest organ, is a better option for drug delivery in many diseases. However, most transdermal delivery is difficult due to the low permeability of therapeutics across the various skin layers. There have been many innovations in transdermal drug delivery to enhance the therapeutic efficacy of the drugs administered. Microneedles (MN), micron sized needles, are of great interest to scientists as a new therapeutic vehicle through transdermal routes, especially for vaccines, drugs, small molecules, etc.Areas covered: This review covers new insights into different types of MNs such as solid, hollow, coated and dissolving MNs (SMNs, HMNs, CMNs, and DMNs) for selected biomedical applications in detail. Specific focus has been given to CMNs and DMNs for vaccine and drug delivery applications with recent developments in new MNs covered.Expert opinion: This review explores the feasibility of innovative MNs used as a drug delivery carrier. Because most of the SMNs and HMNs have many limitations, it is difficult to achieve therapeutic efficacy. Therefore, many scientists are investigating functional modifications of MNs through covalent and non-covalent methods, especially for CMNs and DMNs. The biomedical applications of MNs are growing and new exciting improvements could be achieved, thus resulting in better micro/nano technologies in the near future.
Publisher
TAYLOR FRANCIS LTD
Issue Date
2016-01
Language
English
Article Type
Review
Keywords

RANDOMIZED CONTROLLED SAFETY; INFLUENZA-VIRUS VACCINE; REGULAR HUMAN INSULIN; N-TRIMETHYL CHITOSAN; T-CELL RESPONSES; TRANSDERMAL DELIVERY; INTRADERMAL VACCINATION; HOLLOW MICRONEEDLES; TRANSCUTANEOUS IMMUNIZATION; DISSOLVING MICRONEEDLES

Citation

EXPERT OPINION ON DRUG DELIVERY, v.13, no.1, pp.109 - 131

ISSN
1742-5247
DOI
10.1517/17425247.2016.1115835
URI
http://hdl.handle.net/10203/207183
Appears in Collection
CBE-Journal Papers(저널논문)
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