Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery

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dc.contributor.authorRejinold, N Sanojko
dc.contributor.authorShin, Ju-Hyungko
dc.contributor.authorSeok, Hae Yongko
dc.contributor.authorKim, Yeu-Chunko
dc.date.accessioned2016-05-12T02:58:40Z-
dc.date.available2016-05-12T02:58:40Z-
dc.date.created2015-11-18-
dc.date.created2015-11-18-
dc.date.issued2016-01-
dc.identifier.citationEXPERT OPINION ON DRUG DELIVERY, v.13, no.1, pp.109 - 131-
dc.identifier.issn1742-5247-
dc.identifier.urihttp://hdl.handle.net/10203/207183-
dc.description.abstractIntroduction: The skin, as the largest organ, is a better option for drug delivery in many diseases. However, most transdermal delivery is difficult due to the low permeability of therapeutics across the various skin layers. There have been many innovations in transdermal drug delivery to enhance the therapeutic efficacy of the drugs administered. Microneedles (MN), micron sized needles, are of great interest to scientists as a new therapeutic vehicle through transdermal routes, especially for vaccines, drugs, small molecules, etc.Areas covered: This review covers new insights into different types of MNs such as solid, hollow, coated and dissolving MNs (SMNs, HMNs, CMNs, and DMNs) for selected biomedical applications in detail. Specific focus has been given to CMNs and DMNs for vaccine and drug delivery applications with recent developments in new MNs covered.Expert opinion: This review explores the feasibility of innovative MNs used as a drug delivery carrier. Because most of the SMNs and HMNs have many limitations, it is difficult to achieve therapeutic efficacy. Therefore, many scientists are investigating functional modifications of MNs through covalent and non-covalent methods, especially for CMNs and DMNs. The biomedical applications of MNs are growing and new exciting improvements could be achieved, thus resulting in better micro/nano technologies in the near future.-
dc.languageEnglish-
dc.publisherTAYLOR FRANCIS LTD-
dc.subjectRANDOMIZED CONTROLLED SAFETY-
dc.subjectINFLUENZA-VIRUS VACCINE-
dc.subjectREGULAR HUMAN INSULIN-
dc.subjectN-TRIMETHYL CHITOSAN-
dc.subjectT-CELL RESPONSES-
dc.subjectTRANSDERMAL DELIVERY-
dc.subjectINTRADERMAL VACCINATION-
dc.subjectHOLLOW MICRONEEDLES-
dc.subjectTRANSCUTANEOUS IMMUNIZATION-
dc.subjectDISSOLVING MICRONEEDLES-
dc.titleBiomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery-
dc.typeArticle-
dc.identifier.wosid000368447300005-
dc.identifier.scopusid2-s2.0-84955213105-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue1-
dc.citation.beginningpage109-
dc.citation.endingpage131-
dc.citation.publicationnameEXPERT OPINION ON DRUG DELIVERY-
dc.identifier.doi10.1517/17425247.2016.1115835-
dc.contributor.localauthorKim, Yeu-Chun-
dc.contributor.nonIdAuthorRejinold, N Sanoj-
dc.type.journalArticleReview-
dc.subject.keywordAuthordrug delivery-
dc.subject.keywordAuthormicroneedles-
dc.subject.keywordAuthortypes of-
dc.subject.keywordAuthorvaccine delivery-
dc.subject.keywordAuthormicroneedles-
dc.subject.keywordPlusRANDOMIZED CONTROLLED SAFETY-
dc.subject.keywordPlusINFLUENZA-VIRUS VACCINE-
dc.subject.keywordPlusREGULAR HUMAN INSULIN-
dc.subject.keywordPlusN-TRIMETHYL CHITOSAN-
dc.subject.keywordPlusT-CELL RESPONSES-
dc.subject.keywordPlusTRANSDERMAL DELIVERY-
dc.subject.keywordPlusINTRADERMAL VACCINATION-
dc.subject.keywordPlusHOLLOW MICRONEEDLES-
dc.subject.keywordPlusTRANSCUTANEOUS IMMUNIZATION-
dc.subject.keywordPlusDISSOLVING MICRONEEDLES-
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