On-chip colorimetric biosensor based on polydiacetylene (PDA) embedded in photopolymerized poly(ethylene glycol) diacrylate (PEG-DA) hydrogel

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We have developed a new strategy to construct a colorimetric biosensor on a miniaturized platform. Polydiacetylene (PDA), which is widely known to change color by external stimuli, was employed as a sensing material. To construct a gel-based portable colorimetric biosensor using PDA, PDA was incorporated into poly(ethylene glycol) (PEG)-based hydrogel upon photopolymerization and PDA-embedded PEG hydrogel matrix was patterned within PDMS-based microfluidic channels. The resulting intrachannel hydrogel matrix containing PDA was reacted with alpha-cyclodextrin as a model target sample, which causes a color change of PDA from blue to red. Parallel analyses were performed inside microchannels for multiple solutions containing different amounts of alpha-cyclodextrin and color change gradients were successfully demonstrated depending on the contacting time and amount of alpha-cyclodextrin. (c) 2005 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE SA
Issue Date
2006-04
Language
English
Article Type
Article; Proceedings Paper
Keywords

MOLECULAR RECOGNITION; MICROFLUIDIC SYSTEMS; FABRICATION; LIPOSOMES; VESICLES; SURFACES; FILMS; SILANIZATION; TRANSITION; MONOLAYERS

Citation

BIOCHEMICAL ENGINEERING JOURNAL, v.29, no.1, pp.103 - 108

ISSN
1369-703X
DOI
10.1016/j.bej.2005.02.025
URI
http://hdl.handle.net/10203/19929
Appears in Collection
CBE-Journal Papers(저널논문)
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