On-chip colorimetric biosensor based on polydiacetylene (PDA) embedded in photopolymerized poly(ethylene glycol) diacrylate (PEG-DA) hydrogel

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dc.contributor.authorLee, NYko
dc.contributor.authorJung, YKko
dc.contributor.authorPark, Hyun Gyuko
dc.date.accessioned2010-11-15T06:48:10Z-
dc.date.available2010-11-15T06:48:10Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2006-04-
dc.identifier.citationBIOCHEMICAL ENGINEERING JOURNAL, v.29, no.1, pp.103 - 108-
dc.identifier.issn1369-703X-
dc.identifier.urihttp://hdl.handle.net/10203/19929-
dc.description.abstractWe have developed a new strategy to construct a colorimetric biosensor on a miniaturized platform. Polydiacetylene (PDA), which is widely known to change color by external stimuli, was employed as a sensing material. To construct a gel-based portable colorimetric biosensor using PDA, PDA was incorporated into poly(ethylene glycol) (PEG)-based hydrogel upon photopolymerization and PDA-embedded PEG hydrogel matrix was patterned within PDMS-based microfluidic channels. The resulting intrachannel hydrogel matrix containing PDA was reacted with alpha-cyclodextrin as a model target sample, which causes a color change of PDA from blue to red. Parallel analyses were performed inside microchannels for multiple solutions containing different amounts of alpha-cyclodextrin and color change gradients were successfully demonstrated depending on the contacting time and amount of alpha-cyclodextrin. (c) 2005 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipThis research was supported by the Brain Korea 21 (BK 21) and Center for Ultramicrochemical Process Systems (CUPS) projects.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherELSEVIER SCIENCE SA-
dc.subjectMOLECULAR RECOGNITION-
dc.subjectMICROFLUIDIC SYSTEMS-
dc.subjectFABRICATION-
dc.subjectLIPOSOMES-
dc.subjectVESICLES-
dc.subjectSURFACES-
dc.subjectFILMS-
dc.subjectSILANIZATION-
dc.subjectTRANSITION-
dc.subjectMONOLAYERS-
dc.titleOn-chip colorimetric biosensor based on polydiacetylene (PDA) embedded in photopolymerized poly(ethylene glycol) diacrylate (PEG-DA) hydrogel-
dc.typeArticle-
dc.identifier.wosid000236563700016-
dc.identifier.scopusid2-s2.0-33644983518-
dc.type.rimsART-
dc.citation.volume29-
dc.citation.issue1-
dc.citation.beginningpage103-
dc.citation.endingpage108-
dc.citation.publicationnameBIOCHEMICAL ENGINEERING JOURNAL-
dc.identifier.doi10.1016/j.bej.2005.02.025-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Hyun Gyu-
dc.contributor.nonIdAuthorLee, NY-
dc.contributor.nonIdAuthorJung, YK-
dc.type.journalArticleArticle; Proceedings Paper-
dc.subject.keywordAuthorbiosensors-
dc.subject.keywordAuthorscale-down-
dc.subject.keywordAuthorpolydiacetylene-
dc.subject.keywordAuthorhydrogel-
dc.subject.keywordAuthorimmobilization-
dc.subject.keywordAuthoroptimization-
dc.subject.keywordPlusMOLECULAR RECOGNITION-
dc.subject.keywordPlusMICROFLUIDIC SYSTEMS-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordPlusLIPOSOMES-
dc.subject.keywordPlusVESICLES-
dc.subject.keywordPlusSURFACES-
dc.subject.keywordPlusFILMS-
dc.subject.keywordPlusSILANIZATION-
dc.subject.keywordPlusTRANSITION-
dc.subject.keywordPlusMONOLAYERS-
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