Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.
Publisher
MACMILLAN MAGAZINES LTD
Issue Date
1997-04
Language
ENG
Keywords

MEIOTIC CHROMOSOME SYNAPSIS; CANCER SUSCEPTIBILITY GENE; FAMILIAL BREAST; OVARIAN-CANCER; RECA HOMOLOGS; PROTEIN; REPAIR; MOUSE; YEAST; RECOMBINATION

Citation

NATURE, v.386, no.6627, pp.804 - 810

ISSN
0028-0836
DOI
10.1038/386804a0
URI
http://hdl.handle.net/10203/74833
Appears in Collection
BS-Journal Papers(저널논문)
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