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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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dc.contributor.authorSharan, Shyam K.ko
dc.contributor.authorMorimatsu, Masamiko
dc.contributor.authorAlbrecht, Ursko
dc.contributor.authorLim, Dae-Sikko
dc.contributor.authorRegel, Evako
dc.contributor.authorDinh, Christopherko
dc.contributor.authorSands, Arthurko
dc.contributor.authorEichele, Gregorko
dc.contributor.authorHasty, Paulko
dc.contributor.authorBradley, Allanko
dc.date.accessioned2013-03-02T18:04:36Z-
dc.date.available2013-03-02T18:04:36Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1997-04-
dc.identifier.citationNATURE, v.386, no.6627, pp.804 - 810-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10203/74833-
dc.description.abstractInherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.-
dc.languageEnglish-
dc.publisherMACMILLAN MAGAZINES LTD-
dc.subjectMEIOTIC CHROMOSOME SYNAPSIS-
dc.subjectCANCER SUSCEPTIBILITY GENE-
dc.subjectFAMILIAL BREAST-
dc.subjectOVARIAN-CANCER-
dc.subjectRECA HOMOLOGS-
dc.subjectPROTEIN-
dc.subjectREPAIR-
dc.subjectMOUSE-
dc.subjectYEAST-
dc.subjectRECOMBINATION-
dc.titleEmbryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2-
dc.typeArticle-
dc.identifier.wosidA1997WV70600046-
dc.identifier.scopusid2-s2.0-0030933762-
dc.type.rimsART-
dc.citation.volume386-
dc.citation.issue6627-
dc.citation.beginningpage804-
dc.citation.endingpage810-
dc.citation.publicationnameNATURE-
dc.identifier.doi10.1038/386804a0-
dc.contributor.localauthorLim, Dae-Sik-
dc.contributor.nonIdAuthorSharan, Shyam K.-
dc.contributor.nonIdAuthorMorimatsu, Masami-
dc.contributor.nonIdAuthorAlbrecht, Urs-
dc.contributor.nonIdAuthorRegel, Eva-
dc.contributor.nonIdAuthorDinh, Christopher-
dc.contributor.nonIdAuthorSands, Arthur-
dc.contributor.nonIdAuthorEichele, Gregor-
dc.contributor.nonIdAuthorHasty, Paul-
dc.contributor.nonIdAuthorBradley, Allan-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMEIOTIC CHROMOSOME SYNAPSIS-
dc.subject.keywordPlusCANCER SUSCEPTIBILITY GENE-
dc.subject.keywordPlusFAMILIAL BREAST-
dc.subject.keywordPlusOVARIAN-CANCER-
dc.subject.keywordPlusRECA HOMOLOGS-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusREPAIR-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusYEAST-
dc.subject.keywordPlusRECOMBINATION-
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BS-Journal Papers(저널논문)
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