DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Jisang | ko |
dc.contributor.author | Rejinold, N. Sanoj | ko |
dc.contributor.author | Lee, DaeYong | ko |
dc.contributor.author | Noh, Ilkoo | ko |
dc.contributor.author | Koh, Won-Gun | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.date.accessioned | 2020-02-05T08:20:20Z | - |
dc.date.available | 2020-02-05T08:20:20Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.created | 2020-02-04 | - |
dc.date.created | 2020-02-04 | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.citation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.6, no.1, pp.494 - 504 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | http://hdl.handle.net/10203/272119 | - |
dc.description.abstract | Branched polymers as drug delivery carriers have been widely attempted due to their outstanding drug loading capability and complex stability like branched polyethyleneimine (B-PEI). However, branched polymers without biodegradability may cause toxicity as they can accumulate in the body. Herein, we report branched modified nonaarginine (B-mR9) composed of redox-cleavable disulfide bonds to form stable complexes with methotrexate (MTX) as an anticancer agent, which is further coated with hyaluronic acid (HA). The HA-coated nano-particles provide targetability for the CD44 cell surface receptor. The B-mR9-MTX/HA can effectively aid in intracellular MTX delivery to CD44 overexpressing cancer cells being degradable by the reducing environments of the cancer cells. The B-mR9-MTX/HA exhibits not only a glutathione-triggered degradability but also an outstanding CD44-mediated MTX delivery efficacy. In addition, its superior tumor inhibition capability was confirmed through an in vivo study. The results suggest that the HA-coated B-mR9 nanoparticle can be used as a drug delivery platform. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | CD44-Mediated Methotrexate Delivery by Hyaluronan-Coated Nanoparticles Composed of a Branched Cell-Penetrating Peptide | - |
dc.type | Article | - |
dc.identifier.wosid | 000507429200045 | - |
dc.identifier.scopusid | 2-s2.0-85077642443 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 494 | - |
dc.citation.endingpage | 504 | - |
dc.citation.publicationname | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.identifier.doi | 10.1021/acsbiomaterials.9b01724 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Koh, Won-Gun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cell-penetrating peptide (CPP) | - |
dc.subject.keywordAuthor | branched polymer | - |
dc.subject.keywordAuthor | CD44 receptor | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | methotrexate | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | DIHYDROFOLATE-REDUCTASE | - |
dc.subject.keywordPlus | ANTITUMOR EFFICACY | - |
dc.subject.keywordPlus | PROTEIN DELIVERY | - |
dc.subject.keywordPlus | ACID HYDROGELS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
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