Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease

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We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-beta, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of acetylcholinesterase. Such a framework with multifunctionality could be useful for developing chemical reagents to advance our understanding of multifaceted pathologies of neurodegenerative disorders, including Alzheimer's disease.
Publisher
AMER CHEMICAL SOC
Issue Date
2019-08
Language
English
Article Type
Article
Citation

ACS CHEMICAL NEUROSCIENCE, v.10, no.8, pp.3386 - 3390

ISSN
1948-7193
DOI
10.1021/acschemneuro.9b00232
URI
http://hdl.handle.net/10203/267485
Appears in Collection
CH-Journal Papers(저널논문)
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