DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Geewoo | ko |
dc.contributor.author | Ji, Yonghwan | ko |
dc.contributor.author | Lee, Hyuck Jin | ko |
dc.contributor.author | Kang, Juhye | ko |
dc.contributor.author | Yi, Yelim | ko |
dc.contributor.author | Kim, Mingeun | ko |
dc.contributor.author | Lin, Yuxi | ko |
dc.contributor.author | Lee, Young-Ho | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2019-09-17T03:20:12Z | - |
dc.date.available | 2019-09-17T03:20:12Z | - |
dc.date.created | 2019-09-16 | - |
dc.date.created | 2019-09-16 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | ACS CHEMICAL NEUROSCIENCE, v.10, no.8, pp.3386 - 3390 | - |
dc.identifier.issn | 1948-7193 | - |
dc.identifier.uri | http://hdl.handle.net/10203/267485 | - |
dc.description.abstract | We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-beta, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of acetylcholinesterase. Such a framework with multifunctionality could be useful for developing chemical reagents to advance our understanding of multifaceted pathologies of neurodegenerative disorders, including Alzheimer's disease. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000482546100010 | - |
dc.identifier.scopusid | 2-s2.0-85068166172 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 3386 | - |
dc.citation.endingpage | 3390 | - |
dc.citation.publicationname | ACS CHEMICAL NEUROSCIENCE | - |
dc.identifier.doi | 10.1021/acschemneuro.9b00232 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Nam, Geewoo | - |
dc.contributor.nonIdAuthor | Ji, Yonghwan | - |
dc.contributor.nonIdAuthor | Lee, Hyuck Jin | - |
dc.contributor.nonIdAuthor | Kang, Juhye | - |
dc.contributor.nonIdAuthor | Kim, Mingeun | - |
dc.contributor.nonIdAuthor | Lin, Yuxi | - |
dc.contributor.nonIdAuthor | Lee, Young-Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Multifunctionality | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordAuthor | amyloid-beta | - |
dc.subject.keywordAuthor | metal-amyloid-beta | - |
dc.subject.keywordAuthor | free radicals | - |
dc.subject.keywordAuthor | acetylcholinesterase | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY RELATIONSHIPS | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | METAL-FREE | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | FIBRILLATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | OXIDATION | - |
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