Total Synthesis of (−)-FD-838 and (−)-Cephalimysin A

Abstract

We completed a nine-step total synthesis of (−)-FD-838 and (−)-cephalimysin A. Our synthesis features a biogenetically guided assembly of the highly oxidized spirocyclic core by Snider-type tandem epoxidations of the chiral substrate derived from an amino acid derivative. Our synthetic approach provides a general and versatile solution to access spirocyclic PKS-NRPS-based secondary fungal metabolites.