Total Synthesis of (−)-FD-838 and (−)-Cephalimysin A

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We completed a nine-step total synthesis of (−)-FD-838 and (−)-cephalimysin A. Our synthesis features a biogenetically guided assembly of the highly oxidized spirocyclic core by Snider-type tandem epoxidations of the chiral substrate derived from an amino acid derivative. Our synthetic approach provides a general and versatile solution to access spirocyclic PKS-NRPS-based secondary fungal metabolites.
Publisher
AMER CHEMICAL SOC
Issue Date
2019-07
Language
English
Article Type
Article
Citation

ORGANIC LETTERS, v.21, no.15, pp.6045 - 6049

ISSN
1523-7060
DOI
10.1021/acs.orglett.9b02203
URI
http://hdl.handle.net/10203/264035
Appears in Collection
CH-Journal Papers(저널논문)
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