Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site

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In Saccharomyces cerevisiae, the ATP-dependent chromatin remodeler, Chd1p, globally affects nucleosome positioning at coding regions, where nucleosomes are specifically and directionally aligned with respect to the transcription start site (TSS). Various auxiliary domains of remodelers play critical roles by performing specialized functions that are unique to the type of remodeler. Here, we report that yeast Chd1p directly binds to acetylated histone H3K36 (H3K36Ac) via its chromodomain, and that H3K36Ac stimulates the nucleosome sliding activity of Chd1p in vitro. Furthermore, we use genome-wide analysis to demonstrate that H3K36Ac promotes the remodeling activity of Chd1p to maintain chromatin stability at the 5' ends of genes in vivo. Our work linking Chd1p with H3K36Ac provides novel insights into how the nucleosome remodeling activity of Chd1p is controlled near the TSS. (C) 2018 Elsevier Inc. All rights reserved.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2018-09
Language
English
Article Type
Article
Keywords

SACCHAROMYCES-CEREVISIAE; RECOMBINANT HISTONES; CHROMATIN REMODELER; CHROMODOMAINS; BINDING; HETEROCHROMATIN; IDENTIFICATION; ORGANIZATION; METHYLATION; SWI/SNF

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.503, no.3, pp.1200 - 1206

ISSN
0006-291X
DOI
10.1016/j.bbrc.2018.07.025
URI
http://hdl.handle.net/10203/246164
Appears in Collection
CH-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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