Flexible wireless powered drug delivery system for targeted administration on cerebral cortex

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The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2018-09
Language
English
Article Type
Article
Keywords

IN-VIVO; ELECTRODE ARRAY; GOLD; OPTOGENETICS; CHLORIDE; RELEASE; DEVICE; BIOCOMPATIBILITY; CLASSIFICATION; SEIZURES

Citation

NANO ENERGY, v.51, pp.102 - 112

ISSN
2211-2855
DOI
10.1016/j.nanoen.2018.06.015
URI
http://hdl.handle.net/10203/245174
Appears in Collection
RIMS Journal PapersBS-Journal Papers(저널논문)MS-Journal Papers(저널논문)
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