Posttranscriptional Crossregulation between Drosha and DGCR8

Cited 264 time in webofscience Cited 0 time in scopus
  • Hit : 131
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorHan, Jinjuko
dc.contributor.authorPedersen, Jakob S.ko
dc.contributor.authorKwon, S. Chulko
dc.contributor.authorBelair, Cassandra D.ko
dc.contributor.authorKim, Young-Kookko
dc.contributor.authorYeom, Kyu-Hyeonko
dc.contributor.authorYang, Woo-Youngko
dc.contributor.authorHaussler, Davidko
dc.contributor.authorBlelloch, Robertko
dc.contributor.authorKim, V. Narryko
dc.date.accessioned2017-03-28T06:59:08Z-
dc.date.available2017-03-28T06:59:08Z-
dc.date.created2017-03-08-
dc.date.created2017-03-08-
dc.date.issued2009-01-
dc.identifier.citationCELL, v.136, no.1, pp.75 - 84-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10203/221043-
dc.description.abstractThe Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart from miRNA processing. Here, we report that Drosha and DGCR8 regulate each other posttranscriptionally. The Drosha-DGCR8 complex cleaves the hairpin structures embedded in the DGCR8 mRNA and thereby destabilizes the mRNA. We further find that DGCR8 stabilizes the Drosha protein via protein-protein interaction. This crossregulation between Drosha and DGCR8 may contribute to the homeostatic control of miRNA biogenesis. Furthermore, microarray analyses suggest that a number of mRNAs may be downregulated in a Microprocessor-dependent, miRNA-independent manner. Our study reveals a previously unsuspected function of Microprocessor in mRNA stability control.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectMICROPROCESSOR COMPLEX-
dc.subjectMICRORNA BIOGENESIS-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectRNA INTERFERENCE-
dc.subjectEXPRESSION-
dc.subjectPROLIFERATION-
dc.subjectDROSOPHILA-
dc.subjectMIR-222-
dc.subjectPATHWAY-
dc.subjectCELLS-
dc.titlePosttranscriptional Crossregulation between Drosha and DGCR8-
dc.typeArticle-
dc.identifier.wosid000262318400016-
dc.identifier.scopusid2-s2.0-58149097010-
dc.type.rimsART-
dc.citation.volume136-
dc.citation.issue1-
dc.citation.beginningpage75-
dc.citation.endingpage84-
dc.citation.publicationnameCELL-
dc.identifier.doi10.1016/j.cell.2008.10.053-
dc.contributor.localauthorHan, Jinju-
dc.contributor.nonIdAuthorPedersen, Jakob S.-
dc.contributor.nonIdAuthorKwon, S. Chul-
dc.contributor.nonIdAuthorBelair, Cassandra D.-
dc.contributor.nonIdAuthorKim, Young-Kook-
dc.contributor.nonIdAuthorYeom, Kyu-Hyeon-
dc.contributor.nonIdAuthorYang, Woo-Young-
dc.contributor.nonIdAuthorHaussler, David-
dc.contributor.nonIdAuthorBlelloch, Robert-
dc.contributor.nonIdAuthorKim, V. Narry-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMICROPROCESSOR COMPLEX-
dc.subject.keywordPlusMICRORNA BIOGENESIS-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusRNA INTERFERENCE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusDROSOPHILA-
dc.subject.keywordPlusMIR-222-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusCELLS-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 264 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0