T(H)2 cells and their cytokines regulate formation and function of lymphatic vessels

Cited 33 time in webofscience Cited 0 time in scopus
  • Hit : 513
  • Download : 169
Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we show the negative effects of T helper type 2 (T(H)2) cells and their cytokines on LV formation. IL-4 and IL-13 downregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube formation. Co-culture of LECs with T(H)2 cells also inhibits tube formation, but this effect is fully reversed by interleukin (IL)-4 and/or IL-13 neutralization. Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the density but also enhances the function of lung LVs. These results demonstrate an anti-lymphangiogenic function of T(H)2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2015-02
Language
English
Article Type
Article
Keywords

DISEASE; LYMPHANGIOGENESIS; VASCULATURE; INTERLEUKIN-4; ANGIOGENESIS; ENDOTHELIUM; RECEPTOR; SYSTEM; DIFFERENTIATION; INFLAMMATION

Citation

NATURE COMMUNICATIONS, v.6

ISSN
2041-1723
DOI
10.1038/ncomms7196
URI
http://hdl.handle.net/10203/195923
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 33 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0