T(H)2 cells and their cytokines regulate formation and function of lymphatic vessels

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dc.contributor.authorShin, Ki-Hyukko
dc.contributor.authorKataru, Raghu P.ko
dc.contributor.authorPark, Hyeung Juko
dc.contributor.authorKwon, Bo-Inko
dc.contributor.authorKim, Tae Wooko
dc.contributor.authorHong, Young Kwonko
dc.contributor.authorLee, Seung-Hyoko
dc.date.accessioned2015-04-08T07:57:21Z-
dc.date.available2015-04-08T07:57:21Z-
dc.date.created2015-03-30-
dc.date.created2015-03-30-
dc.date.created2015-03-30-
dc.date.issued2015-02-
dc.identifier.citationNATURE COMMUNICATIONS, v.6-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/195923-
dc.description.abstractLymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we show the negative effects of T helper type 2 (T(H)2) cells and their cytokines on LV formation. IL-4 and IL-13 downregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube formation. Co-culture of LECs with T(H)2 cells also inhibits tube formation, but this effect is fully reversed by interleukin (IL)-4 and/or IL-13 neutralization. Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the density but also enhances the function of lung LVs. These results demonstrate an anti-lymphangiogenic function of T(H)2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleT(H)2 cells and their cytokines regulate formation and function of lymphatic vessels-
dc.typeArticle-
dc.identifier.wosid000350201100005-
dc.identifier.scopusid2-s2.0-84929679692-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/ncomms7196-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Seung-Hyo-
dc.contributor.nonIdAuthorKim, Tae Woo-
dc.contributor.nonIdAuthorHong, Young Kwon-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusLYMPHANGIOGENESIS-
dc.subject.keywordPlusVASCULATURE-
dc.subject.keywordPlusINTERLEUKIN-4-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusENDOTHELIUM-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusINFLAMMATION-
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