DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Ki-Hyuk | ko |
dc.contributor.author | Kataru, Raghu P. | ko |
dc.contributor.author | Park, Hyeung Ju | ko |
dc.contributor.author | Kwon, Bo-In | ko |
dc.contributor.author | Kim, Tae Woo | ko |
dc.contributor.author | Hong, Young Kwon | ko |
dc.contributor.author | Lee, Seung-Hyo | ko |
dc.date.accessioned | 2015-04-08T07:57:21Z | - |
dc.date.available | 2015-04-08T07:57:21Z | - |
dc.date.created | 2015-03-30 | - |
dc.date.created | 2015-03-30 | - |
dc.date.created | 2015-03-30 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195923 | - |
dc.description.abstract | Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we show the negative effects of T helper type 2 (T(H)2) cells and their cytokines on LV formation. IL-4 and IL-13 downregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube formation. Co-culture of LECs with T(H)2 cells also inhibits tube formation, but this effect is fully reversed by interleukin (IL)-4 and/or IL-13 neutralization. Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the density but also enhances the function of lung LVs. These results demonstrate an anti-lymphangiogenic function of T(H)2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | T(H)2 cells and their cytokines regulate formation and function of lymphatic vessels | - |
dc.type | Article | - |
dc.identifier.wosid | 000350201100005 | - |
dc.identifier.scopusid | 2-s2.0-84929679692 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms7196 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Seung-Hyo | - |
dc.contributor.nonIdAuthor | Kim, Tae Woo | - |
dc.contributor.nonIdAuthor | Hong, Young Kwon | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | VASCULATURE | - |
dc.subject.keywordPlus | INTERLEUKIN-4 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ENDOTHELIUM | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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