This paper presents a design methodology based on the distributed actuation principle to achieve a high-performance robot manipulator. Spatial movement of the actuation points provides several advantages such as high payload capacity, high efficiency and a light weight structure for the proposed robot manipulator. Based on the analysis, the distributed actuation mechanism using a single slider is adopted for the proposed manipulator. A prototype of the manipulator with two degrees of freedom is developed and controlled as an example. The efficacy of the proposed approach is verified experimentally.