Immunosenescent CD8(+) T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension

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The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by interferon (IFN), IFN -induced protein 10, and IFN-inducible T-cell chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8(+) T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8(+) T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8(+) T cells may offer new opportunities for the prevention and treatment of human hypertension.
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Issue Date
2013-07
Language
English
Article Type
Article
Keywords

II-INDUCED HYPERTENSION; RHEUMATOID-ARTHRITIS; DISEASE; ASSOCIATION; LYMPHOCYTES; MECHANISMS; GRANZYME; SUBSETS; OBESITY; CXCR3

Citation

HYPERTENSION, v.62, no.1, pp.126 - 133

ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.113.00689
URI
http://hdl.handle.net/10203/175029
Appears in Collection
MSE-Journal Papers(저널논문)
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