DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, Jong-Chan | ko |
dc.contributor.author | Yu, Hee-Tae | ko |
dc.contributor.author | Lim, Beom-Jin | ko |
dc.contributor.author | Koh, Myoung-Ju | ko |
dc.contributor.author | Lee, Jin-O | ko |
dc.contributor.author | Chang, Dong-Yeop | ko |
dc.contributor.author | Choi, Yoon-Seok | ko |
dc.contributor.author | Lee, Sang-Hak | ko |
dc.contributor.author | Kang, Seok-Min | ko |
dc.contributor.author | Jang, Yang-Soo | ko |
dc.contributor.author | Yoo, Ook-Joon | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Park, Sung-Ha | ko |
dc.date.accessioned | 2013-08-14T01:09:27Z | - |
dc.date.available | 2013-08-14T01:09:27Z | - |
dc.date.created | 2013-08-09 | - |
dc.date.created | 2013-08-09 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | HYPERTENSION, v.62, no.1, pp.126 - 133 | - |
dc.identifier.issn | 0194-911X | - |
dc.identifier.uri | http://hdl.handle.net/10203/175029 | - |
dc.description.abstract | The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by interferon (IFN), IFN -induced protein 10, and IFN-inducible T-cell chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8(+) T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8(+) T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8(+) T cells may offer new opportunities for the prevention and treatment of human hypertension. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | II-INDUCED HYPERTENSION | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | DISEASE | - |
dc.subject | ASSOCIATION | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | MECHANISMS | - |
dc.subject | GRANZYME | - |
dc.subject | SUBSETS | - |
dc.subject | OBESITY | - |
dc.subject | CXCR3 | - |
dc.title | Immunosenescent CD8(+) T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension | - |
dc.type | Article | - |
dc.identifier.wosid | 000320302600024 | - |
dc.identifier.scopusid | 2-s2.0-84880736883 | - |
dc.type.rims | ART | - |
dc.citation.volume | 62 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 126 | - |
dc.citation.endingpage | 133 | - |
dc.citation.publicationname | HYPERTENSION | - |
dc.identifier.doi | 10.1161/HYPERTENSIONAHA.113.00689 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Yoo, Ook-Joon | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Youn, Jong-Chan | - |
dc.contributor.nonIdAuthor | Yu, Hee-Tae | - |
dc.contributor.nonIdAuthor | Lim, Beom-Jin | - |
dc.contributor.nonIdAuthor | Koh, Myoung-Ju | - |
dc.contributor.nonIdAuthor | Lee, Jin-O | - |
dc.contributor.nonIdAuthor | Lee, Sang-Hak | - |
dc.contributor.nonIdAuthor | Kang, Seok-Min | - |
dc.contributor.nonIdAuthor | Jang, Yang-Soo | - |
dc.contributor.nonIdAuthor | Park, Sung-Ha | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | chemokine | - |
dc.subject.keywordAuthor | hypertension | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordPlus | II-INDUCED HYPERTENSION | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GRANZYME | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CXCR3 | - |
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