Injectable and sustained delivery of human growth hormone using chemically modified pluronic copolymer hydrogels

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A new injectable biodegradable hydrogel system with thermosensitive sol-gel transition behavior was developed. A series of A-B-A triblock copolymers consisting of Pluronic copolymer end-capped with D- or L-lactic acid oligomers (PL-LAn) with various chain lengths (n = 5,12) was synthesized. It was assumed that a pair of two triblock copolymers with enantiomeric oligolactide chains, when blended in an equimolar mixture, would form more stable, self-assembled, and stereocomplexed (ST) hydrogels. A series of blend hydrogels encapsulating human growth hormone (hGH) was prepared by varying blend ratios between PL and stereocomplexed PL copolymers. They showed sustained release of hGH via an erosion-dependent mechanism. The hydrogel with a 5% blending ratio exhibited the most delayed mass erosion as well as sustained protein release patterns in vitro possibly due to the formation of a fish-net like 3-D mesh structure. The effect of incubation condition on hGH release and degradation behaviors was also assessed.
Publisher
Wiley-Blackwell
Issue Date
2008-05
Language
English
Citation

BIOTECHNOLOGY JOURNAL, v.3, no.5, pp.669 - 675

ISSN
1860-6768
URI
http://hdl.handle.net/10203/13280
Appears in Collection
NT-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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