Injectable and sustained delivery of human growth hormone using chemically modified pluronic copolymer hydrogels

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dc.contributor.authorPark S.Y.ko
dc.contributor.authorChung, Hyun Jungko
dc.contributor.authorLee Y.ko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-11-25-
dc.date.available2009-11-25-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2008-05-
dc.identifier.citationBIOTECHNOLOGY JOURNAL, v.3, no.5, pp.669 - 675-
dc.identifier.issn1860-6768-
dc.identifier.urihttp://hdl.handle.net/10203/13280-
dc.description.abstractA new injectable biodegradable hydrogel system with thermosensitive sol-gel transition behavior was developed. A series of A-B-A triblock copolymers consisting of Pluronic copolymer end-capped with D- or L-lactic acid oligomers (PL-LAn) with various chain lengths (n = 5,12) was synthesized. It was assumed that a pair of two triblock copolymers with enantiomeric oligolactide chains, when blended in an equimolar mixture, would form more stable, self-assembled, and stereocomplexed (ST) hydrogels. A series of blend hydrogels encapsulating human growth hormone (hGH) was prepared by varying blend ratios between PL and stereocomplexed PL copolymers. They showed sustained release of hGH via an erosion-dependent mechanism. The hydrogel with a 5% blending ratio exhibited the most delayed mass erosion as well as sustained protein release patterns in vitro possibly due to the formation of a fish-net like 3-D mesh structure. The effect of incubation condition on hGH release and degradation behaviors was also assessed.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherWiley-Blackwell-
dc.titleInjectable and sustained delivery of human growth hormone using chemically modified pluronic copolymer hydrogels-
dc.typeArticle-
dc.identifier.scopusid2-s2.0-44949238722-
dc.type.rimsART-
dc.citation.volume3-
dc.citation.issue5-
dc.citation.beginningpage669-
dc.citation.endingpage675-
dc.citation.publicationnameBIOTECHNOLOGY JOURNAL-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorChung, Hyun Jung-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorPark S.Y.-
dc.contributor.nonIdAuthorLee Y.-
dc.subject.keywordAuthorHydrogel-
dc.subject.keywordAuthorInjectable-
dc.subject.keywordAuthorProtein delivery-
dc.subject.keywordAuthorStereocomplex-
dc.subject.keywordAuthorThermosensitive-

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