DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park S.Y. | ko |
dc.contributor.author | Chung, Hyun Jung | ko |
dc.contributor.author | Lee Y. | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-25 | - |
dc.date.available | 2009-11-25 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | BIOTECHNOLOGY JOURNAL, v.3, no.5, pp.669 - 675 | - |
dc.identifier.issn | 1860-6768 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13280 | - |
dc.description.abstract | A new injectable biodegradable hydrogel system with thermosensitive sol-gel transition behavior was developed. A series of A-B-A triblock copolymers consisting of Pluronic copolymer end-capped with D- or L-lactic acid oligomers (PL-LAn) with various chain lengths (n = 5,12) was synthesized. It was assumed that a pair of two triblock copolymers with enantiomeric oligolactide chains, when blended in an equimolar mixture, would form more stable, self-assembled, and stereocomplexed (ST) hydrogels. A series of blend hydrogels encapsulating human growth hormone (hGH) was prepared by varying blend ratios between PL and stereocomplexed PL copolymers. They showed sustained release of hGH via an erosion-dependent mechanism. The hydrogel with a 5% blending ratio exhibited the most delayed mass erosion as well as sustained protein release patterns in vitro possibly due to the formation of a fish-net like 3-D mesh structure. The effect of incubation condition on hGH release and degradation behaviors was also assessed. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Wiley-Blackwell | - |
dc.title | Injectable and sustained delivery of human growth hormone using chemically modified pluronic copolymer hydrogels | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-44949238722 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 669 | - |
dc.citation.endingpage | 675 | - |
dc.citation.publicationname | BIOTECHNOLOGY JOURNAL | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Chung, Hyun Jung | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Park S.Y. | - |
dc.contributor.nonIdAuthor | Lee Y. | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Injectable | - |
dc.subject.keywordAuthor | Protein delivery | - |
dc.subject.keywordAuthor | Stereocomplex | - |
dc.subject.keywordAuthor | Thermosensitive | - |
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