Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In vivo models were used to evaluate the compound 19r for antidepressive, anxiolytic, and analgesic activity. (C) 2010 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Issue Date
- 2010-09
- Language
- English
- Article Type
- Article
- Keywords
TAIL SUSPENSION TEST; MARBLE-BURYING BEHAVIOR; SEROTONIN REUPTAKE; ANTIDEPRESSANT; MICE; BUPROPION; DOPAMINE; MODEL; COMBINATION; DISORDER
- Citation
BIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.20, no.18, pp.5567 - 5571
- ISSN
- 0960-894X
- Appears in Collection
- CH-Journal Papers(저널논문)
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