DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hee-Man | ko |
dc.contributor.author | Park, Chan-Woo | ko |
dc.contributor.author | Woo, Min-Ah | ko |
dc.contributor.author | Kim, Moon-Il | ko |
dc.contributor.author | Jo, Yeong-Min | ko |
dc.contributor.author | Park, Hyun-Gyu | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-03-09T16:01:54Z | - |
dc.date.available | 2013-03-09T16:01:54Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | BIOMACROMOLECULES, v.11, no.11, pp.2866 - 2872 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/96809 | - |
dc.description.abstract | Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft copolymer for negative contrast enhancement on T(2) weighted MRI. HER2/neu antibodies were conjugated on the surface of poly(amino acid) coated iron oxide nanoparticles for the detection of breast cancer. The antibody-grafted iron oxide nanoparticles (PAION-Ab) were about 31.1 nm in diameter. The T(2) relaxivity of PAION-Ab was 246 L.mmol(-1) sec(-1) greater than that of the commercial product such as Feridex. PAION-Ab showed low cytotoxicity even at relatively high concentrations. Furthermore, Prussian blue staining and in vitro MRI study with SKBR-3, breast cancer cells overexpressing HER2/neu receptors indicated that PAION-Ab exhibited excellent cancer cell detection ability and enhanced signal intensities in the T(2)-weighted image. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | SUPERPARAMAGNETIC NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | MAGNETITE NANOPARTICLES | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | CONTRAST AGENT | - |
dc.subject | ACID) | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | METHOTREXATE | - |
dc.subject | COPOLYMERS | - |
dc.title | HER2/neu Antibody Conjugated Poly(amino acid)-Coated Iron Oxide Nanoparticles for Breast Cancer MR Imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000283810900006 | - |
dc.identifier.scopusid | 2-s2.0-78650356355 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2866 | - |
dc.citation.endingpage | 2872 | - |
dc.citation.publicationname | BIOMACROMOLECULES | - |
dc.identifier.doi | 10.1021/bm100560m | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Hyun-Gyu | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | MAGNETITE NANOPARTICLES | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | CONTRAST AGENT | - |
dc.subject.keywordPlus | ACID) | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordPlus | COPOLYMERS | - |
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