DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung-Ho | ko |
dc.contributor.author | Kang, Sungsoo | ko |
dc.contributor.author | Lee, Sang-Gil | ko |
dc.contributor.author | Jin, Joon-Hyung | ko |
dc.contributor.author | Park, Jong Wan | ko |
dc.contributor.author | Park, Sang Myun | ko |
dc.contributor.author | Jung, Seunho | ko |
dc.contributor.author | Paik, Seung R. | ko |
dc.date.accessioned | 2013-03-08T23:24:11Z | - |
dc.date.available | 2013-03-08T23:24:11Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | ACTA BIOMATERIALIA, v.6, no.12, pp.4689 - 4697 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | http://hdl.handle.net/10203/94641 | - |
dc.description.abstract | The fabrication of biomaterials which serve as functional scaffolds exhibiting diversified effects has been valued. We report here a unique strategy to fibrillate hemoglobin A (HbA), which exhibits multiple photoelectrochemical properties, and a subsequent specific defibrillation procedure. A subtle structural rearrangement of the alpha/beta-subunits within the quaternary structure of HbA is responsible for the HbA fibril formation in the presence of 0.5% CHCl3. The narrow pH dependence of the suprastructure formation around pH 7.4 illustrates the highly sensitive nature of the structural alteration. The CHCl3-induced fibrils become disintegrated by ascorbic acid, indicating that the oxidation-reduction process of the iron within the heme moiety could be involved in stabilization of the fibrillar structures. The electron-transferring property of the iron allows the fibrils to exhibit not only their conductive behavior but also a photodynamic effect generating hydroxyl radicals in the presence of H2O2 with light illumination. A photovoltaic effect is also demonstrated with the HbA fibrils, which generate an electric current on the fibril-coated microelectrode upon irradiation at 405 nm. Taken together, the multiple effects of HbA fibrils and the selective fibrillation/defibrillation procedures could qualify the fibrils to be employed for various future applications in biotechnology, including bio-machine interfaces. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | AMINO-ACID | - |
dc.subject | NEURODEGENERATIVE DISEASES | - |
dc.subject | CHEMICAL DIFFERENCE | - |
dc.subject | AMYLOID FIBRILS | - |
dc.subject | ALPHA-SYNUCLEIN | - |
dc.subject | PROTEIN | - |
dc.subject | PEPTIDE | - |
dc.subject | POLYMERIZATION | - |
dc.subject | CYTOSKELETON | - |
dc.subject | HAEMOGLOBIN | - |
dc.title | Fibrillar superstructure formation of hemoglobin A and its conductive, photodynamic and photovoltaic effects | - |
dc.type | Article | - |
dc.identifier.wosid | 000284385300026 | - |
dc.identifier.scopusid | 2-s2.0-77958103720 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 4689 | - |
dc.citation.endingpage | 4697 | - |
dc.citation.publicationname | ACTA BIOMATERIALIA | - |
dc.identifier.doi | 10.1016/j.actbio.2010.06.023 | - |
dc.contributor.localauthor | Park, Jong Wan | - |
dc.contributor.nonIdAuthor | Lee, Jung-Ho | - |
dc.contributor.nonIdAuthor | Kang, Sungsoo | - |
dc.contributor.nonIdAuthor | Lee, Sang-Gil | - |
dc.contributor.nonIdAuthor | Jin, Joon-Hyung | - |
dc.contributor.nonIdAuthor | Park, Sang Myun | - |
dc.contributor.nonIdAuthor | Jung, Seunho | - |
dc.contributor.nonIdAuthor | Paik, Seung R. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bionanotechnology | - |
dc.subject.keywordAuthor | Fibrillation | - |
dc.subject.keywordAuthor | Polymerization | - |
dc.subject.keywordAuthor | Protein engineering | - |
dc.subject.keywordAuthor | Self-assembly | - |
dc.subject.keywordPlus | AMINO-ACID | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | CHEMICAL DIFFERENCE | - |
dc.subject.keywordPlus | AMYLOID FIBRILS | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | HAEMOGLOBIN | - |
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