DC Field | Value | Language |
---|---|---|
dc.contributor.author | Remmers E.F. | ko |
dc.contributor.author | Cosan F. | ko |
dc.contributor.author | Kirino Y. | ko |
dc.contributor.author | Ombrello M.J. | ko |
dc.contributor.author | Abaci N. | ko |
dc.contributor.author | Satorius C. | ko |
dc.contributor.author | Le J.M. | ko |
dc.contributor.author | Yang B. | ko |
dc.contributor.author | Korman B.D. | ko |
dc.contributor.author | Cakiris A. | ko |
dc.contributor.author | Aglar O. | ko |
dc.contributor.author | Emrence Z. | ko |
dc.contributor.author | Azakli H. | ko |
dc.contributor.author | Ustek D. | ko |
dc.contributor.author | Tugal-Tutkun I. | ko |
dc.contributor.author | Akman-Demir G. | ko |
dc.contributor.author | Chen W. | ko |
dc.contributor.author | Amos C.I. | ko |
dc.contributor.author | Dizon M.B. | ko |
dc.contributor.author | Kose A.A. | ko |
dc.contributor.author | Azizlerli G. | ko |
dc.contributor.author | Erer B | ko |
dc.contributor.author | Cho, Young Hun | ko |
dc.date.accessioned | 2013-03-08T21:54:55Z | - |
dc.date.available | 2013-03-08T21:54:55Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | NATURE GENETICS, v.42, no.8, pp.698 - U78 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/10203/94417 | - |
dc.description.abstract | Behcet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behcet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behcet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject | INTERLEUKIN-10 RECEPTOR | - |
dc.subject | LOCI | - |
dc.subject | RISK | - |
dc.subject | GENE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | POLYMORPHISM | - |
dc.subject | PROMOTER | - |
dc.subject | COLITIS | - |
dc.title | Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000280524000015 | - |
dc.identifier.scopusid | 2-s2.0-77955087288 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 698 | - |
dc.citation.endingpage | U78 | - |
dc.citation.publicationname | NATURE GENETICS | - |
dc.identifier.doi | 10.1038/ng.625 | - |
dc.contributor.nonIdAuthor | Remmers E.F. | - |
dc.contributor.nonIdAuthor | Cosan F. | - |
dc.contributor.nonIdAuthor | Kirino Y. | - |
dc.contributor.nonIdAuthor | Ombrello M.J. | - |
dc.contributor.nonIdAuthor | Abaci N. | - |
dc.contributor.nonIdAuthor | Satorius C. | - |
dc.contributor.nonIdAuthor | Le J.M. | - |
dc.contributor.nonIdAuthor | Yang B. | - |
dc.contributor.nonIdAuthor | Korman B.D. | - |
dc.contributor.nonIdAuthor | Cakiris A. | - |
dc.contributor.nonIdAuthor | Aglar O. | - |
dc.contributor.nonIdAuthor | Emrence Z. | - |
dc.contributor.nonIdAuthor | Azakli H. | - |
dc.contributor.nonIdAuthor | Ustek D. | - |
dc.contributor.nonIdAuthor | Tugal-Tutkun I. | - |
dc.contributor.nonIdAuthor | Akman-Demir G. | - |
dc.contributor.nonIdAuthor | Chen W. | - |
dc.contributor.nonIdAuthor | Amos C.I. | - |
dc.contributor.nonIdAuthor | Dizon M.B. | - |
dc.contributor.nonIdAuthor | Kose A.A. | - |
dc.contributor.nonIdAuthor | Azizlerli G. | - |
dc.contributor.nonIdAuthor | Erer B | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | INTERLEUKIN-10 RECEPTOR | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | COLITIS | - |
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