DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Shin-Hyun | ko |
dc.contributor.author | Kim, Jin Woong | ko |
dc.contributor.author | Kim, Do-Hoon | ko |
dc.contributor.author | Han, Sang-Hoon | ko |
dc.contributor.author | Weitz, David A. | ko |
dc.date.accessioned | 2013-03-08T16:56:36Z | - |
dc.date.available | 2013-03-08T16:56:36Z | - |
dc.date.created | 2013-02-08 | - |
dc.date.created | 2013-02-08 | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | SMALL, v.9, no.1, pp.124 - 131 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93650 | - |
dc.description.abstract | Capillary microfluidic devices are used to prepare monodisperse polymersomes consisting of a hydrogel core and a bilayer membrane of amphiphilic diblock-copolymers. To make polymersomes, water-in-oil-in-water double-emulsion drops are prepared as templates through single-step emulsification in a capillary microfluidic device. The amphiphile-laden middle oil phase of the double-emulsion drop dewets from the surface of the innermost water drop, which contains hydrogel prepolymers; this dewetting leads to the formation of a bilayer membrane. Subsequently, the oil phase completely separates from the innermost water drop, leaving a polymersome. Upon UV illumination of the polymersome, the prepolymers encapsulated within the interior are crosslinked, forming a hydrogel core. The hydrogel network within the polymersomes facilitates sustained release of the encapsulated materials and increases the stability of the polymersomes through the formation of a scaffold to support the bilayer. In addition, this approach provides a facile method to make monodisperse hydrogel particles directly dispersed in water. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | BIODEGRADABLE POLYMERSOMES | - |
dc.subject | VESICLES | - |
dc.subject | ENCAPSULATION | - |
dc.subject | MONODISPERSE | - |
dc.title | Polymersomes Containing a Hydrogel Network for High Stability and Controlled Release | - |
dc.type | Article | - |
dc.identifier.wosid | 000312988900015 | - |
dc.identifier.scopusid | 2-s2.0-84872034406 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 124 | - |
dc.citation.endingpage | 131 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201201709 | - |
dc.contributor.localauthor | Kim, Shin-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Jin Woong | - |
dc.contributor.nonIdAuthor | Kim, Do-Hoon | - |
dc.contributor.nonIdAuthor | Han, Sang-Hoon | - |
dc.contributor.nonIdAuthor | Weitz, David A. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | polymersomes | - |
dc.subject.keywordAuthor | microfluidics | - |
dc.subject.keywordAuthor | hydrogels | - |
dc.subject.keywordAuthor | controlled release | - |
dc.subject.keywordAuthor | emulsions | - |
dc.subject.keywordPlus | BIODEGRADABLE POLYMERSOMES | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | MONODISPERSE | - |
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