DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, SH | ko |
dc.contributor.author | Jeong, JH | ko |
dc.contributor.author | Yang, SR | ko |
dc.contributor.author | Kim, BY | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-03-07T20:52:13Z | - |
dc.date.available | 2013-03-07T20:52:13Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS, v.45, no.1B, pp.421 - 425 | - |
dc.identifier.issn | 0021-4922 | - |
dc.identifier.uri | http://hdl.handle.net/10203/91292 | - |
dc.description.abstract | Targeted microbubbles for ultrasound imaging were examined with an avidin-modified gold surface of a surface plasmon resonance (SPR) biosensor. Contrast media of ultrasound (US) imaging were fabricated with dispersions of biotinylated gases (microbubbles) in an aqueous medium and the binding interaction of a targeted microbubble contrast agent was characterized by the refractive index change of the adsorbed layers in the SPR biosensor. The shells of the microbubbles were consisted of a gas-filled layer of lipids and polypeptides. Avidin-biotin interaction as a typical protein-ligand model was investigated on biotinylated polypeptide lipid microbubbles that were functionalized with biotin by directly grafting them to poly(succinimide) (PSI). The targeted microbubbles were below 7 mu m (95%) and their mean diameter was 2.5 mu m. The affinity constant (K-A) of the biotinylated polypeptide lipid-microbubbles from the SPR data (K-A = 9.46 g(-1) L) was about 10 times greater than that of polypeptide lipid microbubbles (K-A = 1.00 g(-1) L). The SPR biosensor may help in the prediction of the in vivo behavior of targeted microbubbles (ultrasound contrast agent) in a flow system and in the design of successful target preparation. | - |
dc.language | English | - |
dc.publisher | INST PURE APPLIED PHYSICS | - |
dc.subject | ULTRASOUND CONTRAST AGENT | - |
dc.subject | POLYPEPTIDE | - |
dc.subject | DELIVERY | - |
dc.subject | SYSTEM | - |
dc.title | Binding evaluation of targeted microbubbles with biotin-avidin interaction by surface plasmon resonance biosensor | - |
dc.type | Article | - |
dc.identifier.wosid | 000235089100013 | - |
dc.identifier.scopusid | 2-s2.0-31844452445 | - |
dc.type.rims | ART | - |
dc.citation.volume | 45 | - |
dc.citation.issue | 1B | - |
dc.citation.beginningpage | 421 | - |
dc.citation.endingpage | 425 | - |
dc.citation.publicationname | JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Cho, SH | - |
dc.contributor.nonIdAuthor | Jeong, JH | - |
dc.contributor.nonIdAuthor | Yang, SR | - |
dc.contributor.nonIdAuthor | Kim, BY | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordAuthor | SPR | - |
dc.subject.keywordAuthor | ultrasound contrast agent | - |
dc.subject.keywordAuthor | targeting | - |
dc.subject.keywordAuthor | microbubbles | - |
dc.subject.keywordAuthor | polypeptide | - |
dc.subject.keywordAuthor | lipid | - |
dc.subject.keywordPlus | ULTRASOUND CONTRAST AGENT | - |
dc.subject.keywordPlus | POLYPEPTIDE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SYSTEM | - |
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