N-Acetyl cysteine and caffeic acid phenethyl ester sensitize astrocytoma cells to Fas-mediated cell death in a redox-dependent manner

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In this study, we investigated the role of reactive oxygen species (ROS) in Fas-induced cell death in human astrocytoma cells. Fas activation increased intracellular ROS levels in a NADPH oxidase- and caspase-dependent manner. ROS inhibitors such as N-acetyl cysteine (NAC) and caffeic acid phenethyl ester (CAPE) dramatically sensitized astocytoma cells to Fas-induced loss of mitochondrial transmembrane potential and subsequent cell death, which were abrogated by pretreatment with z-VAD-fmk, a broad-spectrum caspase inhibitor. These results collectively indicate that NAC and CAPE sensitize astrocytoma cells to Fas-induced apoptosis in a redox-dependent manner, suggesting a potential use in the treatment of malignant brain tumors. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Publisher
ELSEVIER IRELAND LTD
Issue Date
2007-11
Language
English
Article Type
Article
Keywords

HUMAN ASTROGLIAL CELLS; SMOOTH-MUSCLE-CELLS; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; INDUCED APOPTOSIS; CANCER CELLS; SIGNAL-TRANSDUCTION; ACTIVATION; EXPRESSION; CASPASE-3

Citation

CANCER LETTERS, v.257, pp.79 - 86

ISSN
0304-3835
DOI
10.1016/j.canlet.2007.07.006
URI
http://hdl.handle.net/10203/89068
Appears in Collection
BiS-Journal Papers(저널논문)
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