DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, K | ko |
dc.contributor.author | Han, YH | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-07T01:19:59Z | - |
dc.date.available | 2013-03-07T01:19:59Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | CANCER LETTERS, v.257, pp.79 - 86 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89068 | - |
dc.description.abstract | In this study, we investigated the role of reactive oxygen species (ROS) in Fas-induced cell death in human astrocytoma cells. Fas activation increased intracellular ROS levels in a NADPH oxidase- and caspase-dependent manner. ROS inhibitors such as N-acetyl cysteine (NAC) and caffeic acid phenethyl ester (CAPE) dramatically sensitized astocytoma cells to Fas-induced loss of mitochondrial transmembrane potential and subsequent cell death, which were abrogated by pretreatment with z-VAD-fmk, a broad-spectrum caspase inhibitor. These results collectively indicate that NAC and CAPE sensitize astrocytoma cells to Fas-induced apoptosis in a redox-dependent manner, suggesting a potential use in the treatment of malignant brain tumors. (C) 2007 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | HUMAN ASTROGLIAL CELLS | - |
dc.subject | SMOOTH-MUSCLE-CELLS | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | CANCER CELLS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | CASPASE-3 | - |
dc.title | N-Acetyl cysteine and caffeic acid phenethyl ester sensitize astrocytoma cells to Fas-mediated cell death in a redox-dependent manner | - |
dc.type | Article | - |
dc.identifier.wosid | 000250597300008 | - |
dc.identifier.scopusid | 2-s2.0-34648820291 | - |
dc.type.rims | ART | - |
dc.citation.volume | 257 | - |
dc.citation.beginningpage | 79 | - |
dc.citation.endingpage | 86 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.identifier.doi | 10.1016/j.canlet.2007.07.006 | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Choi, K | - |
dc.contributor.nonIdAuthor | Han, YH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caffeic acid phenethyl ester | - |
dc.subject.keywordAuthor | fas | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | n-acetyl cysteine | - |
dc.subject.keywordPlus | HUMAN ASTROGLIAL CELLS | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CASPASE-3 | - |
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