DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huh Y.-J. | ko |
dc.contributor.author | Kim J.-M. | ko |
dc.contributor.author | Kim H. | ko |
dc.contributor.author | Song H. | ko |
dc.contributor.author | So H. | ko |
dc.contributor.author | Lee S.Y. | ko |
dc.contributor.author | Kwon S.B. | ko |
dc.contributor.author | Kim H.J. | ko |
dc.contributor.author | Kim H.-H. | ko |
dc.contributor.author | Lee S.H. | ko |
dc.contributor.author | Choi Y. | ko |
dc.contributor.author | Chung S.-C. | ko |
dc.contributor.author | Jeong D.-W. | ko |
dc.contributor.author | Min B.-M. | ko |
dc.date.accessioned | 2013-03-06T17:28:22Z | - |
dc.date.available | 2013-03-06T17:28:22Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | CELL DEATH AND DIFFERENTIATION, v.13, no.7, pp.1138 - 1146 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | http://hdl.handle.net/10203/87782 | - |
dc.description.abstract | This study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/ GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the gamma-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-kappa B and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | IN-VIVO | - |
dc.subject | BONE-RESORPTION | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | ACTIVATION | - |
dc.subject | CELL | - |
dc.subject | SUPEROXIDE | - |
dc.subject | INHIBITION | - |
dc.subject | OXIDASE | - |
dc.title | Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors | - |
dc.type | Article | - |
dc.identifier.wosid | 000238802500011 | - |
dc.identifier.scopusid | 2-s2.0-33745218280 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1138 | - |
dc.citation.endingpage | 1146 | - |
dc.citation.publicationname | CELL DEATH AND DIFFERENTIATION | - |
dc.identifier.doi | 10.1038/sj.cdd.4401793 | - |
dc.contributor.localauthor | Song H. | - |
dc.contributor.nonIdAuthor | Huh Y.-J. | - |
dc.contributor.nonIdAuthor | Kim J.-M. | - |
dc.contributor.nonIdAuthor | Kim H. | - |
dc.contributor.nonIdAuthor | So H. | - |
dc.contributor.nonIdAuthor | Lee S.Y. | - |
dc.contributor.nonIdAuthor | Kwon S.B. | - |
dc.contributor.nonIdAuthor | Kim H.J. | - |
dc.contributor.nonIdAuthor | Kim H.-H. | - |
dc.contributor.nonIdAuthor | Lee S.H. | - |
dc.contributor.nonIdAuthor | Choi Y. | - |
dc.contributor.nonIdAuthor | Chung S.-C. | - |
dc.contributor.nonIdAuthor | Jeong D.-W. | - |
dc.contributor.nonIdAuthor | Min B.-M. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | GSH/GSSG ratio | - |
dc.subject.keywordAuthor | Osteoclastogenesis | - |
dc.subject.keywordAuthor | RANKL-dependent signaling | - |
dc.subject.keywordAuthor | Reactive oxygen species (ROS) | - |
dc.subject.keywordAuthor | Redox status | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BONE-RESORPTION | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | OXIDASE | - |
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