DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park S. | ko |
dc.contributor.author | Gwak J. | ko |
dc.contributor.author | Cho M. | ko |
dc.contributor.author | Song T. | ko |
dc.contributor.author | Won J. | ko |
dc.contributor.author | Kim D.-E. | ko |
dc.contributor.author | Shin J.-G. | ko |
dc.contributor.author | Oh S. | ko |
dc.date.accessioned | 2013-03-06T17:22:45Z | - |
dc.date.available | 2013-03-06T17:22:45Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | MOLECULAR PHARMACOLOGY, v.70, no.3, pp.960 - 966 | - |
dc.identifier.issn | 0026-895X | - |
dc.identifier.uri | http://hdl.handle.net/10203/87766 | - |
dc.description.abstract | Aberrant activation of Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) is a critical event in the development of human colon cancer. Thus, Wnt/beta-catenin signaling is an attractive target for the development of anticancer therapeutics. In this study, we identified hexachlorophene as an inhibitor of Wnt/beta-catenin signaling from cell-based small-molecule screening. Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin. This degradation pathway is Siah-1 and adenomatous polyposis colidependent, but glycogen synthase kinase-3 beta and F-box beta-transducin repeat-containing protein-independent. In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells. Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation. | - |
dc.language | English | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.subject | COLON-CANCER CELLS | - |
dc.subject | UBIQUITIN-PROTEASOME PATHWAY | - |
dc.subject | TUMOR SUPPRESSION | - |
dc.subject | HUMAN HOMOLOG | - |
dc.subject | WNT PATHWAY | - |
dc.subject | CYCLIN D1 | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEIN | - |
dc.subject | APC | - |
dc.subject | TARGET | - |
dc.title | Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation | - |
dc.type | Article | - |
dc.identifier.wosid | 000239922300019 | - |
dc.identifier.scopusid | 2-s2.0-33747597785 | - |
dc.type.rims | ART | - |
dc.citation.volume | 70 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 960 | - |
dc.citation.endingpage | 966 | - |
dc.citation.publicationname | MOLECULAR PHARMACOLOGY | - |
dc.identifier.doi | 10.1124/mol.106.024729 | - |
dc.contributor.localauthor | Won J. | - |
dc.contributor.nonIdAuthor | Park S. | - |
dc.contributor.nonIdAuthor | Gwak J. | - |
dc.contributor.nonIdAuthor | Cho M. | - |
dc.contributor.nonIdAuthor | Song T. | - |
dc.contributor.nonIdAuthor | Kim D.-E. | - |
dc.contributor.nonIdAuthor | Shin J.-G. | - |
dc.contributor.nonIdAuthor | Oh S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COLON-CANCER CELLS | - |
dc.subject.keywordPlus | UBIQUITIN-PROTEASOME PATHWAY | - |
dc.subject.keywordPlus | TUMOR SUPPRESSION | - |
dc.subject.keywordPlus | HUMAN HOMOLOG | - |
dc.subject.keywordPlus | WNT PATHWAY | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | APC | - |
dc.subject.keywordPlus | TARGET | - |
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