DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park D. | ko |
dc.contributor.author | Lee S. | ko |
dc.contributor.author | Bolser D. | ko |
dc.contributor.author | Schroeder M. | ko |
dc.contributor.author | Lappe M. | ko |
dc.contributor.author | Oh D. | ko |
dc.contributor.author | Bhak J. | ko |
dc.date.accessioned | 2013-03-06T12:03:11Z | - |
dc.date.available | 2013-03-06T12:03:11Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | BIOINFORMATICS, v.21, no.15, pp.3234 - 3240 | - |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.uri | http://hdl.handle.net/10203/86930 | - |
dc.description.abstract | Motivation: Many genomes have been completely sequenced. However, detecting and analyzing their protein-protein interactions by experimental methods such as co-immunoprecipitation, tandem affinity purification and Y2H is not as fast as genome sequencing. Therefore, a computational prediction method based on the known protein structural interactions will be useful to analyze large-scale protein-protein interaction rules within and among complete genomes. Results: We confirmed that all the predicted protein family interactomes (the full set of protein family interactions within a proteome) of 146 species are scale-free networks, and they share a small core network comprising 36 protein families related to indispensable cellular functions. We found two fundamental differences among prokaryotic and eukaryotic interactomes: (1) eukarya had significantly more hub families than archaea and bacteria and (2) certain special hub families determined the topology of the eukaryotic interactomes. Our comparative analysis suggests that a very small number of expansive protein families led to the evolution of interactomes and seemed tohave played a key role in species diversification. Contact: jong@kribb.re.kr Supplementary information: http://interactomics.org | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | COMPARATIVE GENOMICS | - |
dc.subject | GENE ONTOLOGY | - |
dc.subject | DATABASE | - |
dc.subject | EVOLUTION | - |
dc.subject | SEQUENCES | - |
dc.subject | CLASSIFICATION | - |
dc.subject | EUKARYOTES | - |
dc.subject | BACTERIAL | - |
dc.subject | BIOLOGY | - |
dc.subject | YEAST | - |
dc.title | Comparative interactomics analysis of protein family interaction networks using PSIMAP (protein structural interactome map) | - |
dc.type | Article | - |
dc.identifier.wosid | 000230513200005 | - |
dc.identifier.scopusid | 2-s2.0-25144431896 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 15 | - |
dc.citation.beginningpage | 3234 | - |
dc.citation.endingpage | 3240 | - |
dc.citation.publicationname | BIOINFORMATICS | - |
dc.identifier.doi | 10.1093/bioinformatics/bti512 | - |
dc.contributor.localauthor | Lee S. | - |
dc.contributor.nonIdAuthor | Park D. | - |
dc.contributor.nonIdAuthor | Bolser D. | - |
dc.contributor.nonIdAuthor | Schroeder M. | - |
dc.contributor.nonIdAuthor | Lappe M. | - |
dc.contributor.nonIdAuthor | Oh D. | - |
dc.contributor.nonIdAuthor | Bhak J. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COMPARATIVE GENOMICS | - |
dc.subject.keywordPlus | GENE ONTOLOGY | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | SEQUENCES | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | EUKARYOTES | - |
dc.subject.keywordPlus | BACTERIAL | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | YEAST | - |
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