DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JS | ko |
dc.contributor.author | Nam, YoonSung | ko |
dc.contributor.author | Kang, BY | ko |
dc.contributor.author | Han, SH | ko |
dc.contributor.author | Chang, IS | ko |
dc.date.accessioned | 2013-03-04T13:17:58Z | - |
dc.date.available | 2013-03-04T13:17:58Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.citation | JOURNAL OF APPLIED POLYMER SCIENCE, v.92, pp.517 - 522 | - |
dc.identifier.issn | 0021-8995 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82759 | - |
dc.description.abstract | To stabilize vitamin A in a cosmetic/dermatological formulation, we present here a new encapsulation method based on polymer microspheres having a localized "proton-buffering" capacity. Poly(methyl methacrylate)-g-polyethylenimine (PNMA-g-PEI) was prepared by direct condensation grafting of PEI onto poly(methyl methacrylate-co-methyl acrylic acid). The reaction was confirmed by FT-IR analysis showing the amide vibration at 1,550 cm(-1). Elemental analysis indicated that the weight content of the grafted PEI was 1.6% (w/w). Vitamin A was encapsulated into PMMA-g-PEI microspheres by using an oil-in-water (O/W) single emulsion method. The presence of PEI moiety dramatically improved the chemical stability of vitamin A in microspheres. Vitamin A encapsulated within PMMA-g-PEI microspheres maintained 91% of its initial activity after 30-day incubation at 40degreesC, while only maintaining 60% within plain PMMA microspheres. This study demonstrates that proton-buffering within hydrophobic polymer matrix is a useful strategy for stabilizing "acid-labile" active ingredients. (C) 2004 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.publisher | JOHN WILEY & SONS INC | - |
dc.subject | POLY(VINYL ALCOHOL) | - |
dc.subject | RELEASE | - |
dc.subject | MICROPARTICLES | - |
dc.subject | RETINOL | - |
dc.subject | SKIN | - |
dc.subject | STABILIZATION | - |
dc.subject | MECHANISM | - |
dc.subject | DELIVERY | - |
dc.title | Vitamin A microencapsulation within poly(methyl methacrylate)-g-polyethylenimine microspheres: Localized proton buffering effect on vitamin A stability | - |
dc.type | Article | - |
dc.identifier.wosid | 000189150900066 | - |
dc.identifier.scopusid | 2-s2.0-1542577155 | - |
dc.type.rims | ART | - |
dc.citation.volume | 92 | - |
dc.citation.beginningpage | 517 | - |
dc.citation.endingpage | 522 | - |
dc.citation.publicationname | JOURNAL OF APPLIED POLYMER SCIENCE | - |
dc.identifier.doi | 10.1002/app.20028 | - |
dc.contributor.localauthor | Nam, YoonSung | - |
dc.contributor.nonIdAuthor | Lee, JS | - |
dc.contributor.nonIdAuthor | Kang, BY | - |
dc.contributor.nonIdAuthor | Han, SH | - |
dc.contributor.nonIdAuthor | Chang, IS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | graft copolymers | - |
dc.subject.keywordAuthor | microencapsulation | - |
dc.subject.keywordAuthor | stabilization | - |
dc.subject.keywordAuthor | functionalization of polymers | - |
dc.subject.keywordAuthor | polyimines | - |
dc.subject.keywordPlus | POLY(VINYL ALCOHOL) | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | RETINOL | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | DELIVERY | - |
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