Thalamic control of visceral nociception mediated by T-type Calcium channels

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Sensations from viscera, like fullness, easily become painful if the stimulus persists. Mice lacking alpha1G T-type Ca2+ channels show hyperalgesia to visceral pain. Thalamic infusion of a T-type blocker induced similar hyperalgesia in wild-type mice. In response to visceral pain, the ventroposterolateral thalamic neurons evokeda surge of single spikes, which then slowly decayed as T type-dependent burst spikes gradually increased. In alpha1G-deficient neurons, the single-spike response persisted without burst spikes. These results indicate that T-type Ca2+ channels underlie an antinociceptive mechanism operating in the thalamus andsupport the idea that burst firing plays a critical role in sensory gating in the thalamus.
Publisher
Amer Assoc Advancement Science
Issue Date
2003-10
Language
English
Article Type
Article
Keywords

THALAMOCORTICAL RELAY; CALCIUM CHANNELS; DORSAL COLUMN; SPINAL-CORD; NEURONS; BURST; RESPONSES; PATHWAY; NUCLEUS; RATS

Citation

SCIENCE, v.302, no.0, pp.117 - 119

ISSN
0036-8075
DOI
10.1126/science.1088886
URI
http://hdl.handle.net/10203/82729
Appears in Collection
BS-Journal Papers(저널논문)
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