DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Park, Donghyun | ko |
dc.contributor.author | Choi, Soonwook | ko |
dc.contributor.author | Lee, Sukchan | ko |
dc.contributor.author | Sun, Minjeong | ko |
dc.contributor.author | Kim, Chanki | ko |
dc.contributor.author | Shin, Hee-Sup | ko |
dc.date.accessioned | 2013-03-04T13:06:08Z | - |
dc.date.available | 2013-03-04T13:06:08Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-10 | - |
dc.identifier.citation | SCIENCE, v.302, no.0, pp.117 - 119 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82729 | - |
dc.description.abstract | Sensations from viscera, like fullness, easily become painful if the stimulus persists. Mice lacking alpha1G T-type Ca2+ channels show hyperalgesia to visceral pain. Thalamic infusion of a T-type blocker induced similar hyperalgesia in wild-type mice. In response to visceral pain, the ventroposterolateral thalamic neurons evokeda surge of single spikes, which then slowly decayed as T type-dependent burst spikes gradually increased. In alpha1G-deficient neurons, the single-spike response persisted without burst spikes. These results indicate that T-type Ca2+ channels underlie an antinociceptive mechanism operating in the thalamus andsupport the idea that burst firing plays a critical role in sensory gating in the thalamus. | - |
dc.language | English | - |
dc.publisher | Amer Assoc Advancement Science | - |
dc.subject | THALAMOCORTICAL RELAY | - |
dc.subject | CALCIUM CHANNELS | - |
dc.subject | DORSAL COLUMN | - |
dc.subject | SPINAL-CORD | - |
dc.subject | NEURONS | - |
dc.subject | BURST | - |
dc.subject | RESPONSES | - |
dc.subject | PATHWAY | - |
dc.subject | NUCLEUS | - |
dc.subject | RATS | - |
dc.title | Thalamic control of visceral nociception mediated by T-type Calcium channels | - |
dc.type | Article | - |
dc.identifier.wosid | 000185678500049 | - |
dc.type.rims | ART | - |
dc.citation.volume | 302 | - |
dc.citation.issue | 0 | - |
dc.citation.beginningpage | 117 | - |
dc.citation.endingpage | 119 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.1088886 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Park, Donghyun | - |
dc.contributor.nonIdAuthor | Choi, Soonwook | - |
dc.contributor.nonIdAuthor | Lee, Sukchan | - |
dc.contributor.nonIdAuthor | Sun, Minjeong | - |
dc.contributor.nonIdAuthor | Kim, Chanki | - |
dc.contributor.nonIdAuthor | Shin, Hee-Sup | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | THALAMOCORTICAL RELAY | - |
dc.subject.keywordPlus | CALCIUM CHANNELS | - |
dc.subject.keywordPlus | DORSAL COLUMN | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | BURST | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | RATS | - |
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