Thalamic control of visceral nociception mediated by T-type Calcium channels

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dc.contributor.authorKim, Daesooko
dc.contributor.authorPark, Donghyunko
dc.contributor.authorChoi, Soonwookko
dc.contributor.authorLee, Sukchanko
dc.contributor.authorSun, Minjeongko
dc.contributor.authorKim, Chankiko
dc.contributor.authorShin, Hee-Supko
dc.date.accessioned2013-03-04T13:06:08Z-
dc.date.available2013-03-04T13:06:08Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-10-
dc.identifier.citationSCIENCE, v.302, no.0, pp.117 - 119-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10203/82729-
dc.description.abstractSensations from viscera, like fullness, easily become painful if the stimulus persists. Mice lacking alpha1G T-type Ca2+ channels show hyperalgesia to visceral pain. Thalamic infusion of a T-type blocker induced similar hyperalgesia in wild-type mice. In response to visceral pain, the ventroposterolateral thalamic neurons evokeda surge of single spikes, which then slowly decayed as T type-dependent burst spikes gradually increased. In alpha1G-deficient neurons, the single-spike response persisted without burst spikes. These results indicate that T-type Ca2+ channels underlie an antinociceptive mechanism operating in the thalamus andsupport the idea that burst firing plays a critical role in sensory gating in the thalamus.-
dc.languageEnglish-
dc.publisherAmer Assoc Advancement Science-
dc.subjectTHALAMOCORTICAL RELAY-
dc.subjectCALCIUM CHANNELS-
dc.subjectDORSAL COLUMN-
dc.subjectSPINAL-CORD-
dc.subjectNEURONS-
dc.subjectBURST-
dc.subjectRESPONSES-
dc.subjectPATHWAY-
dc.subjectNUCLEUS-
dc.subjectRATS-
dc.titleThalamic control of visceral nociception mediated by T-type Calcium channels-
dc.typeArticle-
dc.identifier.wosid000185678500049-
dc.type.rimsART-
dc.citation.volume302-
dc.citation.issue0-
dc.citation.beginningpage117-
dc.citation.endingpage119-
dc.citation.publicationnameSCIENCE-
dc.identifier.doi10.1126/science.1088886-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.nonIdAuthorPark, Donghyun-
dc.contributor.nonIdAuthorChoi, Soonwook-
dc.contributor.nonIdAuthorLee, Sukchan-
dc.contributor.nonIdAuthorSun, Minjeong-
dc.contributor.nonIdAuthorKim, Chanki-
dc.contributor.nonIdAuthorShin, Hee-Sup-
dc.type.journalArticleArticle-
dc.subject.keywordPlusTHALAMOCORTICAL RELAY-
dc.subject.keywordPlusCALCIUM CHANNELS-
dc.subject.keywordPlusDORSAL COLUMN-
dc.subject.keywordPlusSPINAL-CORD-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusBURST-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusNUCLEUS-
dc.subject.keywordPlusRATS-
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