Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2

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The plasma membrane Na+/Ca2+ exchanger (NCX) plays a role in regulation of intracellular Ca2+ concentration via the forward mode (Ca2+ efflux) or the reverse mode (Ca2+ influx). To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain. Mutant hippocampal neurons exhibited a significantly delayed clearance of elevated Ca2+ following depolarization. The frequency threshold for LTP and LTD in the hippocampal CA1 region was shifted to a lowered frequency in the mutant mice, thereby favoring LTP. Behaviorally, the mutant mice exhibited enhanced performance in several hippocampus-dependent learning and memory tasks. These results demonstrate that NCX2 can be a temporal regulator of Ca2+ homeostasis and as such is essential for the control of synaptic plasticity and cognition.
Publisher
CELL PRESS
Issue Date
2003-06
Language
English
Article Type
Article
Keywords

LONG-TERM POTENTIATION; SODIUM-CALCIUM EXCHANGE; CALMODULIN KINASE-II; CRAYFISH NEUROMUSCULAR-JUNCTION; DEPENDENT SYNAPTIC PLASTICITY; RAT-BRAIN; NA+-CA2+ EXCHANGER; INTRACELLULAR CALCIUM; NEURONAL PREPARATIONS; MOLECULAR-CLONING

Citation

NEURON, v.38, no.6, pp.965 - 976

ISSN
0896-6273
DOI
10.1016/S0896-6273(03)00334-9
URI
http://hdl.handle.net/10203/81721
Appears in Collection
BiS-Journal Papers(저널논문)
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