Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2

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dc.contributor.authorJeon, Daejongko
dc.contributor.authorYang, YMko
dc.contributor.authorJeong, MJko
dc.contributor.authorPhilipson, KDko
dc.contributor.authorRhim, Hko
dc.contributor.authorShin, HSko
dc.date.accessioned2013-03-04T03:24:31Z-
dc.date.available2013-03-04T03:24:31Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-06-
dc.identifier.citationNEURON, v.38, no.6, pp.965 - 976-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10203/81721-
dc.description.abstractThe plasma membrane Na+/Ca2+ exchanger (NCX) plays a role in regulation of intracellular Ca2+ concentration via the forward mode (Ca2+ efflux) or the reverse mode (Ca2+ influx). To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain. Mutant hippocampal neurons exhibited a significantly delayed clearance of elevated Ca2+ following depolarization. The frequency threshold for LTP and LTD in the hippocampal CA1 region was shifted to a lowered frequency in the mutant mice, thereby favoring LTP. Behaviorally, the mutant mice exhibited enhanced performance in several hippocampus-dependent learning and memory tasks. These results demonstrate that NCX2 can be a temporal regulator of Ca2+ homeostasis and as such is essential for the control of synaptic plasticity and cognition.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectLONG-TERM POTENTIATION-
dc.subjectSODIUM-CALCIUM EXCHANGE-
dc.subjectCALMODULIN KINASE-II-
dc.subjectCRAYFISH NEUROMUSCULAR-JUNCTION-
dc.subjectDEPENDENT SYNAPTIC PLASTICITY-
dc.subjectRAT-BRAIN-
dc.subjectNA+-CA2+ EXCHANGER-
dc.subjectINTRACELLULAR CALCIUM-
dc.subjectNEURONAL PREPARATIONS-
dc.subjectMOLECULAR-CLONING-
dc.titleEnhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2-
dc.typeArticle-
dc.identifier.wosid000183691400015-
dc.identifier.scopusid2-s2.0-0037523361-
dc.type.rimsART-
dc.citation.volume38-
dc.citation.issue6-
dc.citation.beginningpage965-
dc.citation.endingpage976-
dc.citation.publicationnameNEURON-
dc.identifier.doi10.1016/S0896-6273(03)00334-9-
dc.contributor.localauthorJeon, Daejong-
dc.contributor.nonIdAuthorYang, YM-
dc.contributor.nonIdAuthorJeong, MJ-
dc.contributor.nonIdAuthorPhilipson, KD-
dc.contributor.nonIdAuthorRhim, H-
dc.contributor.nonIdAuthorShin, HS-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusSODIUM-CALCIUM EXCHANGE-
dc.subject.keywordPlusCALMODULIN KINASE-II-
dc.subject.keywordPlusCRAYFISH NEUROMUSCULAR-JUNCTION-
dc.subject.keywordPlusDEPENDENT SYNAPTIC PLASTICITY-
dc.subject.keywordPlusRAT-BRAIN-
dc.subject.keywordPlusNA+-CA2+ EXCHANGER-
dc.subject.keywordPlusINTRACELLULAR CALCIUM-
dc.subject.keywordPlusNEURONAL PREPARATIONS-
dc.subject.keywordPlusMOLECULAR-CLONING-
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