DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jovine, L | ko |
dc.contributor.author | Park, Jong, H | ko |
dc.contributor.author | Wassarman, PM | ko |
dc.date.accessioned | 2013-03-04T00:27:50Z | - |
dc.date.available | 2013-03-04T00:27:50Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-11 | - |
dc.identifier.citation | BMC CELL BIOLOGY, v.3 | - |
dc.identifier.issn | 1471-2121 | - |
dc.identifier.uri | http://hdl.handle.net/10203/81075 | - |
dc.description.abstract | Background: Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified. Hypothesis: We report that the inner ear protein stereocilin is related in sequence to otoancorin and, based on its localisation and predicted GPI-anchoring, may mediate attachment of the tectorial and otoconial membranes to sensory hair bundles. Testing: It is expected that antibodies directed against stereocilin would specifically label sites of contact between sensory hair cells and tectorial/otoconial membranes of the inner ear. Implications: Our findings support a unified molecular mechanism for mechanotransduction, with stereocilin and otoancorin defining a new protein family responsible for the attachment of acellular gels to both sensory and nonsensory cells of the inner ear. | - |
dc.language | English | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | NON-SYNDROMIC DEAFNESS | - |
dc.subject | TECTORIAL MEMBRANE | - |
dc.subject | MUTATIONS | - |
dc.subject | PROTEIN | - |
dc.subject | MESOTHELIN | - |
dc.title | Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear | - |
dc.type | Article | - |
dc.identifier.wosid | 000179958900001 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.publicationname | BMC CELL BIOLOGY | - |
dc.identifier.doi | 10.1186/1471-2121-3-28 | - |
dc.contributor.localauthor | Park, Jong, H | - |
dc.contributor.nonIdAuthor | Jovine, L | - |
dc.contributor.nonIdAuthor | Wassarman, PM | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NON-SYNDROMIC DEAFNESS | - |
dc.subject.keywordPlus | TECTORIAL MEMBRANE | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MESOTHELIN | - |
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