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Synthesis of 15N Labelled Isophosphoramide Mustard

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dc.contributor.authorEllen M. Shulman-Roskesko
dc.contributor.authorMichael P. Gamcsikko
dc.contributor.authorO. Michael Colvinko
dc.contributor.authorYoung H. Changko
dc.contributor.authorYoung H. Ehangko
dc.contributor.authorSusan M. Ludemanko
dc.date.accessioned2013-02-25T17:21:37Z-
dc.date.available2013-02-25T17:21:37Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1994-03-
dc.identifier.citationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, v.34, no.3, pp.231 - 237-
dc.identifier.issn0362-4803-
dc.identifier.urihttp://hdl.handle.net/10203/63888-
dc.description.abstractThe ifosfamide metabolite isophosphoramide mustard (IPM) was synthesized with isotopic enrichment at each nitrogen site. Glycine-N-15 was converted to 2-chloroethylamine-N-15 hydrochloride (4 steps, 21% net yield) which was then reacted with phenyl dichlorophosphate to provide N,N'-bis(2-chloroethyl)phosphorodiamidic-N-15(2) acid phenyl ester [62%, PhOP(O) ((NHCH2CH2Cl)2)-N-15]. Catalytic hydrogenation of this phenyl ester followed by the addition of cyclohexylamine (CHA) provided IPM-N-15(2) as the CHA salt (63%).-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.subjectPHOSPHORAMIDE MUSTARD-
dc.subjectCYCLOPHOSPHAMIDE ANALOGS-
dc.subjectMETABOLITE-
dc.titleSynthesis of 15N Labelled Isophosphoramide Mustard-
dc.typeArticle-
dc.identifier.wosidA1994NB14500004-
dc.identifier.scopusid2-s2.0-0028280952-
dc.type.rimsART-
dc.citation.volume34-
dc.citation.issue3-
dc.citation.beginningpage231-
dc.citation.endingpage237-
dc.citation.publicationnameJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS-
dc.contributor.localauthorYoung H. Chang-
dc.contributor.nonIdAuthorEllen M. Shulman-Roskes-
dc.contributor.nonIdAuthorMichael P. Gamcsik-
dc.contributor.nonIdAuthorO. Michael Colvin-
dc.contributor.nonIdAuthorYoung H. Ehang-
dc.contributor.nonIdAuthorSusan M. Ludeman-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorN-15(2)-ISOPHOSPHORAMIDE MUSTARD-
dc.subject.keywordAuthor2-CHLOROETHYLAMINE-N-15 HYDROCHLORIDE-
dc.subject.keywordAuthorIFOSFAMIDE METABOLITE-
dc.subject.keywordPlusPHOSPHORAMIDE MUSTARD-
dc.subject.keywordPlusCYCLOPHOSPHAMIDE ANALOGS-
dc.subject.keywordPlusMETABOLITE-
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