DC Field | Value | Language |
---|---|---|
dc.contributor.author | ho kwon kang | ko |
dc.contributor.author | eun ju shin | ko |
dc.contributor.author | sang chul shim | ko |
dc.date.accessioned | 2013-02-25T00:46:13Z | - |
dc.date.available | 2013-02-25T00:46:13Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.12, no.5, pp.554 - 559 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/58500 | - |
dc.description.abstract | The photophysical and photochemical properties of khellin were compared with those of 8-methoxypsoralen (8-MOP). Quantum yields of fluorescence and triplet formation decreases as solvent polarity increases, which is opposite to 8-MOP, and photocycloadditivity of khellin to olefins is much lower than that of 8-MOP. Electron ejection from khellin by laser flash was not observed, but observed from 8-MOP. As models of 4',5'-monoadducts of khellin or 8-MOP with thymine base, khellin <> dimethylfumarate 4',5'-monoadduct (KDF) was also compared with 8-MOP <> thymidine 4',5'-monoadduct (F-2) in those properties to give some insight on the second-step biadduct formation resulting in cross-links of DNA duplex. KDF ad F-2 were very similar to khellin and 8-MOP in photophysical properties, respectively. However, KDF did not form adducts with various olefins, and thus it is thought that 2,3-double bond of chromone moiety in khellin is hardly reactive in contrast with 3, 4-double bond of coumarin moiety in 8-MOP. These results indicate that khellin is fairly photostable compound, a poor type I photodynamic sensitizer and producer of O2.- which is some cause of phototoxic erythemal reactions and undesirable side effects. Therefore khellin is safer to use than 8-MOP in photochemotherapy of some skin diseases. Although khellin is much less reactive than 8-MOP, khellin must be also a monofunctional drug. Since khellin is, however, as effective as 8-MOP in photochemotherapy of some skin diseases, it is suggested that khellin may be different from 8-MOP in the action mechanism. | - |
dc.language | English | - |
dc.publisher | Korean Chemical Soc | - |
dc.subject | RADIATIONLESS TRANSITIONS | - |
dc.subject | EXCITED-STATES | - |
dc.subject | DNA | - |
dc.subject | PSORALENS | - |
dc.subject | TRIPLET | - |
dc.subject | FUROCOUMARINS | - |
dc.subject | LIGHT | - |
dc.subject | C4-CYCLOMONOADDUCT | - |
dc.subject | PHOTOADDUCTS | - |
dc.title | Comparison of the Photophysical and Photochemical Properties of Khelin and 8-Methoxypsoralen | - |
dc.type | Article | - |
dc.identifier.wosid | A1991GP60400025 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 554 | - |
dc.citation.endingpage | 559 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.nonIdAuthor | ho kwon kang | - |
dc.contributor.nonIdAuthor | eun ju shin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RADIATIONLESS TRANSITIONS | - |
dc.subject.keywordPlus | EXCITED-STATES | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | PSORALENS | - |
dc.subject.keywordPlus | TRIPLET | - |
dc.subject.keywordPlus | FUROCOUMARINS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | C4-CYCLOMONOADDUCT | - |
dc.subject.keywordPlus | PHOTOADDUCTS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.