Effect of mechanical and electrical stimulation on breast cell behavior = 기계적, 전기적 자극에 의한 유방세포 반응에 대한 연구

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dc.contributor.advisorShin, Jennifer Hyun-jong-
dc.contributor.advisor신현정-
dc.contributor.authorPark, Na-Rae-
dc.contributor.author박나래-
dc.date.accessioned2011-12-14T06:44:36Z-
dc.date.available2011-12-14T06:44:36Z-
dc.date.issued2009-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=308520&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/45686-
dc.description학위논문(석사) - 한국과학기술원 : 기계공학전공, 2009.2, [ vi, 57 p. ]-
dc.description.abstractCell migration plays an important role in physiological and pathological process $\;t{in vivo}$. It has been reported that cell are exposed to various mechanical forces including tensile, compressive, shear and electrical stresses, and these various external stimulus have an influence on regulating or inducing dynamic cellular responses through mechanotransduction pathway. Therefore, it is necessary to understand the dynamic behavior of cells under the effects of physical stimulation. The objectives of this study is to investigate the effects of shear and electrical stresses on the dynamic behavior of different types of breast cells, MCF-10A (normal), MCF-7 (non-metastatic cancer cells), and MDA-MB-231 (metastatic cancer cells) because breast epithelial cells are exposed to interstitial flow with a minimal shear stress and transepithelial electrical potential difference. We first develop a self-contained incubation system with a parallel plate shear stress and E-field induction chamber. Under various flow and E -field conditions, the dynamic responses of three different cell types are investigated in real-time. Besides, a possible factor which relates to force induced cell motility is studied by depleting external calcium supplement. This study will help us to understand the fundamental mechanisms underlying shear and electrical stimulation induced breast cell behavior.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectBreast epithelial cell-
dc.subjectElectric field-
dc.subjectShear stress-
dc.subjectMotility-
dc.subject유선상피세포-
dc.subject전기장-
dc.subject전단응력-
dc.subject운동성-
dc.subjectBreast epithelial cell-
dc.subjectElectric field-
dc.subjectShear stress-
dc.subjectMotility-
dc.subject유선상피세포-
dc.subject전기장-
dc.subject전단응력-
dc.subject운동성-
dc.titleEffect of mechanical and electrical stimulation on breast cell behavior = 기계적, 전기적 자극에 의한 유방세포 반응에 대한 연구-
dc.typeThesis(Master)-
dc.identifier.CNRN308520/325007 -
dc.description.department한국과학기술원 : 기계공학전공, -
dc.identifier.uid020073175-
dc.contributor.localauthorPark, Na-Rae-
dc.contributor.localauthor박나래-
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