We report on the rapid alloy screening of Ni-Co-Ti-Al-Mo superalloys with high thermal stability and specific yield stress by means of directed energy deposition. A laser directed energy deposition, a specific type of additive manufacturing, was employed using multiple powder feeders and elemental powders. Fifty superalloys of different compositions were deposited and the heat-treated microstructure and gamma' solvus temperature were examined. The 43Ni-38Co-9Ti-6Al-4Mo superalloy (atomic percent composition) exhibited a uniform gamma/gamma' microstructure and a gamma' solvus temperature of 1202 degrees C. The beneficial properties of the superalloy were also found in the cast superalloy of identical composition. The cast superalloy exhibited a thermally stable gamma/gamma' microstructure with cuboidal gamma' precipitates even after long-term aging heat treatments at 800 degrees C, 900 degrees C, and 1000 degrees C up to 500 h. The gamma'-coarsening mechanism was evaluated based on the Lifshitz-Slyozov-Wagner model and the trans-interface diffusion-controlled model. A transition between these two mechanisms was observed with an increase in aging temperature. Atom probe tomography analyses revealed that the sluggish interface diffusion of Co and corresponding reduction of the interfacial energy induced the transition of the gamma'-coarsening mechanism. Moreover, the cast superalloy showed an enhanced specific yield stress attributed to its exceptionally low alloy density of 7.61 g/cm(3).