Cell line which is knock out the bmp receptor genes and a method of producing target proteins using the sameBMP 수용체 유전자가 녹아웃된 형질전환 CHO 세포주 및 이를 이용한 목적 단백질의 생산 방법
The present invention relates to a transgenic CHO cell line in which the BMP receptor gene BMPRIA or BMPRII is knocked out. The BMP type I receptor BMPRIA or BMP type II receptor BMPRII gene which plays an important role in intracellular signal transduction in CHO cells is knocked out to prevent the activation of self concentration control pathway and the signal transduction mediated by BMP in CHO cells, so that the productivity of a target protein to be produced can be improved.