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Lee, Gyun Min (이균민)
교수, Department of Biological Sciences(생명과학과)

http://bs.kaist.ac.kr/~acelab/

Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)
Co-researchers
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    NO Title, Author(s) (Publication Title, Volume Issue, Page, Issue Date)
    1
    Awakening dormant glycosyltransferases in CHO cells with CRISPRa

    Karottki, Karen Julie la Cour; Hefzi, Hooman; Xiong, Kai; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.117, no.2, pp.593 - 598, 2020-02

    2
    Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

    Ha, Tae Kwang; Hansen, Anders Holmgaard; Kildegaard, Helene Faustrup; et al, METABOLIC ENGINEERING, v.57, pp.182 - 192, 2020-01

    3
    Bip Inducer X: an ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

    Ha, Tae Kwang; Hansen, Anders H.; Kildegaard, Helene F.; et al, BIOTECHNOLOGY JOURNAL, v.14, no.10, 2019-10

    4
    Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

    Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E.; et al, TRENDS IN BIOTECHNOLOGY, v.37, no.9, pp.931 - 942, 2019-09

    5
    Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference

    Xiong, Kai; Marquart, Kim Fabiano; Karottki, Karen Julie la Cour; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.116, no.7, pp.1813 - 1819, 2019-06

    6
    Analysis of Golgi pH in Chinese hamster ovary cells using ratiometric pH-sensitive fluorescent proteins

    Lee, Jong Hyun; Kim, Jihoon; Park, Jong-Ho; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.116, no.5, pp.1006 - 1016, 2019-05

    7
    Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

    Pristovsek, Nusa; Nallapareddy, Saranya; Grav, Lise Marie; et al, ACS SYNTHETIC BIOLOGY, v.8, no.4, pp.758 - 774, 2019-04

    8
    Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

    Kim, Che Lin; Lee, Gyun Minresearcher, METABOLIC ENGINEERING, v.52, pp.57 - 67, 2019-03

    9
    Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

    Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; et al, METABOLIC ENGINEERING, v.52, pp.143 - 152, 2019-03

    10
    Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing

    Jae Seong Lee; Park, Jin-Hyoung; Ha, Tae Kwang; et al, ACS SYNTHETIC BIOLOGY, v.7, no.12, pp.2867 - 2878, 2018-12

    11
    Improving the production of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis

    Kim, Che Lin; Jung, Mi Yeong; Kim, Young Sik; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.10, pp.2565 - 2575, 2018-10

    12
    CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3, and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

    Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; et al, BIOTECHNOLOGY JOURNAL, v.13, no.10, 2018-10

    13
    Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting

    Lim, Sung-Min; Park, Sun-Hye; Lee, Joohyoung; et al, JOURNAL OF BIOTECHNOLOGY, v.283, pp.37 - 42, 2018-10

    14
    Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

    Grav, Lise Marie; Sergeeva, Dania; Lee, Jae Seong; et al, ACS SYNTHETIC BIOLOGY, v.7, no.9, pp.2148 - 2159, 2018-09

    15
    Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine

    Baek, Eric H; Lee, Jae Seong; Lee, Gyun Minresearcher, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.9, pp.2243 - 2254, 2018-09

    16
    Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins

    Jeong, Yeong Ran; Kim, Sun Young; Park, Young Sam; et al, JOURNAL OF PHARMACEUTICAL SCIENCES, v.107, no.7, pp.1831 - 1841, 2018-07

    17
    Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells

    Lee, Joohyoung; Park, Jong-Ho; Park, Sun-Hye; et al, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.102, no.11, pp.4729 - 4739, 2018-06

    18
    Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies

    Yu, Da Young; Lee, Sang Yoon; Lee, Gyun Minresearcher, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.5, pp.1367 - 1372, 2018-05

    19
    Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin Alfa, LBDE, and Its Originator Darbepoetin Alfa, NESPA (R)

    Jeong, Yeong Ran; Jeong, Rae Ung; Son, Jeong Hyun; et al, BIODRUGS, v.32, no.2, pp.153 - 168, 2018-04

    20
    Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin-a, LBDE and Originator Darbepoetin-a, NESP®

    Jeong, Yeong Ran; Jeong, Rae Ung; Son, Jeong Hyun; et al, BIODRUGS, v.32, no.2, pp.153 - 168, 2018-04
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