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Lee, Gyun Min (이균민)
교수, Department of Biological Sciences(생명과학과)

http://bs.kaist.ac.kr/~acelab/

Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)
Co-researchers
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    NO Title, Author(s) (Publication Title, Volume Issue, Page, Issue Date)
    1
    Selective Endocytosis Recombinant Human BMPs Through Cell Surface Heparan Sulfate Proteoglycans in CHO Cells: BMP-2 and BMP-7

    Kim, Mi Gyeom; Kim, Che Lin; Kim, Young Sik; et al, SCIENTIFIC REPORTS, v.11, no.1, 2021-12

    2
    A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

    Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan; et al, METABOLIC ENGINEERING, v.66, pp.114 - 122, 2021-07

    3
    Comprehensive characterization of dihydrofolate reductase-mediated gene amplification for the establishment of recombinant human embryonic kidney 293 cells producing monoclonal antibodies

    Lee, Sang Yoon; Baek, Minhye; Lee, Gyun Minresearcher, BIOTECHNOLOGY JOURNAL, v.16, no.5, 2021-05

    4
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; et al, AUTOPHAGY, v.17, no.1, pp.1 - 382, 2021-05

    5
    Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures

    Yoon, Chansik; Kim, Dongil; Lim, Ju Hyeon; et al, BIOTECHNOLOGY JOURNAL, v.15, no.10, 2020-10

    6
    Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

    Sergeeva, Daria; Lee, Gyun Minresearcher; Nielsen, Lars Keld; et al, ACS SYNTHETIC BIOLOGY, v.9, no.9, pp.2546 - 2561, 2020-09

    7
    Comprehensive Analysis of Genomic Safe Harbors as Target Sites for Stable Expression of the Heterologous Gene in HEK293 Cells

    Shin, Seunghyeon; Kim, Su Hyun; Shin, Sung Wook; et al, ACS SYNTHETIC BIOLOGY, v.9, no.6, pp.1263 - 1269, 2020-06

    8
    Multiplex secretome engineering enhances recombinant protein production and purity

    Kol, Stefan; Ley, Daniel; Wulff, Tune L.; et al, NATURE COMMUNICATIONS, v.11, no.1, 2020-04

    9
    Awakening dormant glycosyltransferases in CHO cells with CRISPRa

    Karottki, Karen Julie la Cour; Hefzi, Hooman; Xiong, Kai; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.117, no.2, pp.593 - 598, 2020-02

    10
    Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

    Ha, Tae Kwang; Hansen, Anders Holmgaard; Kildegaard, Helene Faustrup; et al, METABOLIC ENGINEERING, v.57, pp.182 - 192, 2020-01

    11
    Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

    Gutierrez, Jahir M.; Feizi, Amir; Li, Shangzhong; et al, NATURE COMMUNICATIONS, v.11, no.1, pp.1 - 10, 2020-01

    12
    Bip Inducer X: an ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

    Ha, Tae Kwang; Hansen, Anders H.; Kildegaard, Helene F.; et al, BIOTECHNOLOGY JOURNAL, v.14, no.10, 2019-10

    13
    Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

    Lee, Jae Seong; Kildegaard, Helene Faustrup; Lewis, Nathan E.; et al, TRENDS IN BIOTECHNOLOGY, v.37, no.9, pp.931 - 942, 2019-09

    14
    Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference

    Xiong, Kai; Marquart, Kim Fabiano; Karottki, Karen Julie la Cour; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.116, no.7, pp.1813 - 1819, 2019-06

    15
    Analysis of Golgi pH in Chinese hamster ovary cells using ratiometric pH-sensitive fluorescent proteins

    Lee, Jong Hyun; Kim, Jihoon; Park, Jong-Ho; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.116, no.5, pp.1006 - 1016, 2019-05

    16
    Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

    Pristovsek, Nusa; Nallapareddy, Saranya; Grav, Lise Marie; et al, ACS SYNTHETIC BIOLOGY, v.8, no.4, pp.758 - 774, 2019-04

    17
    Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

    Kim, Che Lin; Lee, Gyun Minresearcher, METABOLIC ENGINEERING, v.52, pp.57 - 67, 2019-03

    18
    Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

    Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; et al, METABOLIC ENGINEERING, v.52, pp.143 - 152, 2019-03

    19
    Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing

    Jae Seong Lee; Park, Jin-Hyoung; Ha, Tae Kwang; et al, ACS SYNTHETIC BIOLOGY, v.7, no.12, pp.2867 - 2878, 2018-12

    20
    Improving the production of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis

    Kim, Che Lin; Jung, Mi Yeong; Kim, Young Sik; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.10, pp.2565 - 2575, 2018-10
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