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Lee, Gyun Min (이균민)
교수, Department of Biological Sciences(생명과학과)

http://bs.kaist.ac.kr/~acelab/

Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)
Co-researchers
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    NO Title, Author(s) (Publication Title, Volume Issue, Page, Issue Date)
    1
    Development of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production

    Park, Jong-Ho; Lee, Hoon-Min; Jin, Eun-Ju; et al, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.106, no.9-10, pp.3571 - 3582, 2022-05

    2
    Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures

    Kim, Dongil; Yoon, Chansik; Lee, Gyun Minresearcher, BIOTECHNOLOGY AND BIOENGINEERING, v.119, no.3, pp.820 - 831, 2022-03

    3
    Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

    Ha, Tae Kwang; Kim, Dongil; Kim, Che Lin; et al, BIOTECHNOLOGY ADVANCES, v.54, 2022-01

    4
    Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells

    Kim, Su Hyun; Baek, Minhye; Park, Sungje; et al, METABOLIC ENGINEERING, v.69, pp.73 - 86, 2022-01

    5
    Blockage of undesirable endocytosis of recombinant human growth/differentiation factor-5 in Chinese hamster ovary cell cultures requires heparin analogs with specific chain lengths

    Kim, Mi Gyeom; Lee, Gyun Minresearcher, BIOTECHNOLOGY JOURNAL, v.16, no.10, pp.2100227, 2021-10

    6
    A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

    Shamie, Isaac; Duttke, Sascha H.; Karottki, Karen J. la Cour; et al, NAR GENOMICS AND BIOINFORMATICS, v.3, no.3, 2021-09

    7
    An optimized genome-wide, virus-free CRISPR screen for mammalian cells

    Xiong, Kai; la Cour Karottki, Karen Julie; Hefzi, Hooman; et al, Cell Reports Methods, v.1, no.4, 2021-08

    8
    A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

    Karottki, Karen Julie la Cour; Hefzi, Hooman; Li, Songyuan; et al, METABOLIC ENGINEERING, v.66, pp.114 - 122, 2021-07

    9
    Streamlined Human Cell-Based Recombinase-Mediated Cassette Exchange Platform Enables Multigene Expression for the Production of Therapeutic Proteins

    Shin, Seunghyeon; Kim, Su Hyun; Lee, Jae Seong; et al, ACS SYNTHETIC BIOLOGY, v.10, no.7, pp.1715 - 1727, 2021-07

    10
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; et al, AUTOPHAGY, v.17, no.1, pp.1 - 382, 2021-05

    11
    Comprehensive characterization of dihydrofolate reductase-mediated gene amplification for the establishment of recombinant human embryonic kidney 293 cells producing monoclonal antibodies

    Lee, Sang Yoon; Baek, Minhye; Lee, Gyun Minresearcher, BIOTECHNOLOGY JOURNAL, v.16, no.5, 2021-05

    12
    Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7

    Kim, Mi Gyeom; Kim, Che Lin; Kim, Young Sik; et al, SCIENTIFIC REPORTS, v.11, no.1, 2021-02

    13
    Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures

    Yoon, Chansik; Kim, Dongil; Lim, Ju Hyeon; et al, BIOTECHNOLOGY JOURNAL, v.15, no.10, 2020-10

    14
    Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

    Sergeeva, Daria; Lee, Gyun Minresearcher; Nielsen, Lars Keld; et al, ACS SYNTHETIC BIOLOGY, v.9, no.9, pp.2546 - 2561, 2020-09

    15
    Comprehensive Analysis of Genomic Safe Harbors as Target Sites for Stable Expression of the Heterologous Gene in HEK293 Cells

    Shin, Seunghyeon; Kim, Su Hyun; Shin, Sung Wook; et al, ACS SYNTHETIC BIOLOGY, v.9, no.6, pp.1263 - 1269, 2020-06

    16
    Multiplex secretome engineering enhances recombinant protein production and purity

    Kol, Stefan; Ley, Daniel; Wulff, Tune L.; et al, NATURE COMMUNICATIONS, v.11, no.1, 2020-04

    17
    Awakening dormant glycosyltransferases in CHO cells with CRISPRa

    Karottki, Karen Julie la Cour; Hefzi, Hooman; Xiong, Kai; et al, BIOTECHNOLOGY AND BIOENGINEERING, v.117, no.2, pp.593 - 598, 2020-02

    18
    Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

    Ha, Tae Kwang; Hansen, Anders Holmgaard; Kildegaard, Helene Faustrup; et al, METABOLIC ENGINEERING, v.57, pp.182 - 192, 2020-01

    19
    Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

    Gutierrez, Jahir M.; Feizi, Amir; Li, Shangzhong; et al, NATURE COMMUNICATIONS, v.11, no.1, pp.1 - 10, 2020-01

    20
    Bip Inducer X: an ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

    Ha, Tae Kwang; Hansen, Anders H.; Kildegaard, Helene F.; et al, BIOTECHNOLOGY JOURNAL, v.14, no.10, 2019-10
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